Influence of CFH gene on symptom severity of schizophrenia

Chen Zhang,1 Qinyu Lv,1 Weixing Fan,2 Wei Tang,3 Zhenghui Yi1 1Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 2Department of Psychiatry, Jinhua Second Hospital, Jinhua, 3Department of Psychiatry, Wenzhou Kanging Hospital, Wenzhou, P...

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Autores principales:	Zhang C, Lv QY, Fan WX, Tang W, Yi ZH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Complement factor H Negative symptoms Cognitive dysfunction Hippocampus Schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/12b72433078943fe8139ac8d55198a8c
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spelling	oai:doaj.org-article:12b72433078943fe8139ac8d55198a8c2021-12-02T00:24:59ZInfluence of CFH gene on symptom severity of schizophrenia1178-2021https://doaj.org/article/12b72433078943fe8139ac8d55198a8c2017-03-01T00:00:00Zhttps://www.dovepress.com/influence-of-cfh-gene-on-symptom-severity-of-schizophrenia-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chen Zhang,1 Qinyu Lv,1 Weixing Fan,2 Wei Tang,3 Zhenghui Yi1 1Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 2Department of Psychiatry, Jinhua Second Hospital, Jinhua, 3Department of Psychiatry, Wenzhou Kanging Hospital, Wenzhou, People’s Republic of China Objective: Recent advances have provided compelling evidence for the role of excessive complement activity in the pathophysiology of schizophrenia. In this study, we aimed to detect the association of the gene encoding complement factor H (CFH), a regulator in complement activation, with schizophrenia. Materials and methods: A sample of 1783 individuals with or without schizophrenia was recruited for genetic analysis. Genomic DNA samples were extracted from peripheral blood cells using multiplex polymerase chain reaction and the SNaPshot assay. A Database for Schizophrenia Genetic Research (SZDB) was used to detect the association of brain CFH expression with schizophrenia. Next, we performed a genotype–phenotype analysis to identify the relationship between CFH Y402H polymorphism and clinical features of schizophrenia. Results: There was a significant association of hippocampal CFH expression with schizophrenia (P=0.017), whereas this significance did not survive after adjusting for false discovery rate (P=0.105). Comparing the genotype and allele frequencies of the genotyped single-nucleotide polymorphisms between case and control groups showed no significant difference. There were significant differences in the scores of negative symptoms and delayed memory between the patients with C allele and those without C allele (P<0.01 and P=0.04 after Bonferroni correction, respectively). Furthermore, we observed a marginally significant association between the Y402H polymorphism and CFH expression in the hippocampus (P=0.051); however, this significance was lost after multiple testing correction (P=0.51, after Bonferroni correction). Conclusion: Our findings provide suggestive evidence for the role of CFH in the development of negative symptoms and cognitive dysfunction in schizophrenia. Keywords: complement factor H, negative symptoms, cognitive dysfunction, hippocampus, schizophreniaZhang CLv QYFan WXTang WYi ZHDove Medical PressarticleComplement factor HNegative symptomsCognitive dysfunctionHippocampusSchizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 697-706 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Complement factor H Negative symptoms Cognitive dysfunction Hippocampus Schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Complement factor H Negative symptoms Cognitive dysfunction Hippocampus Schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang C Lv QY Fan WX Tang W Yi ZH Influence of CFH gene on symptom severity of schizophrenia
description	Chen Zhang,1 Qinyu Lv,1 Weixing Fan,2 Wei Tang,3 Zhenghui Yi1 1Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 2Department of Psychiatry, Jinhua Second Hospital, Jinhua, 3Department of Psychiatry, Wenzhou Kanging Hospital, Wenzhou, People’s Republic of China Objective: Recent advances have provided compelling evidence for the role of excessive complement activity in the pathophysiology of schizophrenia. In this study, we aimed to detect the association of the gene encoding complement factor H (CFH), a regulator in complement activation, with schizophrenia. Materials and methods: A sample of 1783 individuals with or without schizophrenia was recruited for genetic analysis. Genomic DNA samples were extracted from peripheral blood cells using multiplex polymerase chain reaction and the SNaPshot assay. A Database for Schizophrenia Genetic Research (SZDB) was used to detect the association of brain CFH expression with schizophrenia. Next, we performed a genotype–phenotype analysis to identify the relationship between CFH Y402H polymorphism and clinical features of schizophrenia. Results: There was a significant association of hippocampal CFH expression with schizophrenia (P=0.017), whereas this significance did not survive after adjusting for false discovery rate (P=0.105). Comparing the genotype and allele frequencies of the genotyped single-nucleotide polymorphisms between case and control groups showed no significant difference. There were significant differences in the scores of negative symptoms and delayed memory between the patients with C allele and those without C allele (P<0.01 and P=0.04 after Bonferroni correction, respectively). Furthermore, we observed a marginally significant association between the Y402H polymorphism and CFH expression in the hippocampus (P=0.051); however, this significance was lost after multiple testing correction (P=0.51, after Bonferroni correction). Conclusion: Our findings provide suggestive evidence for the role of CFH in the development of negative symptoms and cognitive dysfunction in schizophrenia. Keywords: complement factor H, negative symptoms, cognitive dysfunction, hippocampus, schizophrenia
format	article
author	Zhang C Lv QY Fan WX Tang W Yi ZH
author_facet	Zhang C Lv QY Fan WX Tang W Yi ZH
author_sort	Zhang C
title	Influence of CFH gene on symptom severity of schizophrenia
title_short	Influence of CFH gene on symptom severity of schizophrenia
title_full	Influence of CFH gene on symptom severity of schizophrenia
title_fullStr	Influence of CFH gene on symptom severity of schizophrenia
title_full_unstemmed	Influence of CFH gene on symptom severity of schizophrenia
title_sort	influence of cfh gene on symptom severity of schizophrenia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/12b72433078943fe8139ac8d55198a8c
work_keys_str_mv	AT zhangc influenceofcfhgeneonsymptomseverityofschizophrenia AT lvqy influenceofcfhgeneonsymptomseverityofschizophrenia AT fanwx influenceofcfhgeneonsymptomseverityofschizophrenia AT tangw influenceofcfhgeneonsymptomseverityofschizophrenia AT yizh influenceofcfhgeneonsymptomseverityofschizophrenia
_version_	1718403723936399360

Influence of CFH gene on symptom severity of schizophrenia

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