C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis

Abstract We evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP) in patients with ulcerative colitis (UC). Endoscopic scores reflecting the most severe lesion [maximum Mayo...

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Autores principales:	Natsuki Ishida, Tomohiro Higuchi, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/12bc71d40e3c4ffaa23602924245089f
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spelling	oai:doaj.org-article:12bc71d40e3c4ffaa23602924245089f2021-12-02T17:40:48ZC-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis10.1038/s41598-021-90558-z2045-2322https://doaj.org/article/12bc71d40e3c4ffaa23602924245089f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90558-zhttps://doaj.org/toc/2045-2322Abstract We evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP) in patients with ulcerative colitis (UC). Endoscopic scores reflecting the most severe lesion [maximum Mayo Endoscopic Subscore (M-MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS)] and those reflecting the inflammation of the entire colon [sum of MES (S-MES) and Ulcerative Colitis Colonoscopic Index of Severity (UCCIS)] were evaluated. FC, FIT, and CRP were measured, and their association with the four endoscopic scores was evaluated. Endoscopic scores of 78 complete colonoscopies (66 UC patients) were evaluated using the three biomarkers. FC and CRP tended to correlate more strongly with S-MES and UCCIS than with M-MES and UCEIS. In the M-MES 0, 1 group, compared to CRP, FC and FIT showed stronger correlations with S-MES and UCCIS. Conversely, in the M-MES 2, 3 group, only CRP was significantly correlated with each descriptor. CRP more strongly reflects colon-wide mucosal inflammation than FC and allows reliable assessment of inflammation throughout the colon in active UC.Natsuki IshidaTomohiro HiguchiTakahiro MiyazuSatoshi TamuraShinya TaniMihoko YamadeMoriya IwaizumiYasushi HamayaSatoshi OsawaTakahisa FurutaKen SugimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natsuki Ishida Tomohiro Higuchi Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
description	Abstract We evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP) in patients with ulcerative colitis (UC). Endoscopic scores reflecting the most severe lesion [maximum Mayo Endoscopic Subscore (M-MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS)] and those reflecting the inflammation of the entire colon [sum of MES (S-MES) and Ulcerative Colitis Colonoscopic Index of Severity (UCCIS)] were evaluated. FC, FIT, and CRP were measured, and their association with the four endoscopic scores was evaluated. Endoscopic scores of 78 complete colonoscopies (66 UC patients) were evaluated using the three biomarkers. FC and CRP tended to correlate more strongly with S-MES and UCCIS than with M-MES and UCEIS. In the M-MES 0, 1 group, compared to CRP, FC and FIT showed stronger correlations with S-MES and UCCIS. Conversely, in the M-MES 2, 3 group, only CRP was significantly correlated with each descriptor. CRP more strongly reflects colon-wide mucosal inflammation than FC and allows reliable assessment of inflammation throughout the colon in active UC.
format	article
author	Natsuki Ishida Tomohiro Higuchi Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto
author_facet	Natsuki Ishida Tomohiro Higuchi Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto
author_sort	Natsuki Ishida
title	C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
title_short	C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
title_full	C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
title_fullStr	C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
title_full_unstemmed	C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
title_sort	c-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12bc71d40e3c4ffaa23602924245089f
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C-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis

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