Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

Acute kidney injury (AKI) causes a lot of harm to human health but is treated by only supportive therapy in most cases. Recent evidence shows that mesenchymal stem cells (MSCs) benefit kidney regeneration through releasing paracrine factors and extracellular vesicles (EVs) to the recipient kidney ce...

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Autores principales:	Pei-Wen Lee, Bo-Sheng Wu, Chih-Yu Yang, Oscar Kuang-Sheng Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acute kidney injury mesenchymal stem cells extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/12bd90d7e5c54f7d92ec637504c44e8f
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spelling	oai:doaj.org-article:12bd90d7e5c54f7d92ec637504c44e8f2021-11-11T16:52:51ZMolecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury10.3390/ijms2221114061422-00671661-6596https://doaj.org/article/12bd90d7e5c54f7d92ec637504c44e8f2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11406https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Acute kidney injury (AKI) causes a lot of harm to human health but is treated by only supportive therapy in most cases. Recent evidence shows that mesenchymal stem cells (MSCs) benefit kidney regeneration through releasing paracrine factors and extracellular vesicles (EVs) to the recipient kidney cells and are considered to be promising cellular therapy for AKI. To develop more efficient, precise therapies for AKI, we review the therapeutic mechanism of MSCs and MSC-derived EVs in AKI and look for a better understanding of molecular signaling and cellular communication between donor MSCs and recipient kidney cells. We also review recent clinical trials of MSC-EVs in AKI. This review summarizes the molecular mechanisms of MSCs’ therapeutic effects on kidney regeneration, expecting to comprehensively facilitate future clinical application for treating AKI.Pei-Wen LeeBo-Sheng WuChih-Yu YangOscar Kuang-Sheng LeeMDPI AGarticleacute kidney injurymesenchymal stem cellsextracellular vesiclesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11406, p 11406 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute kidney injury mesenchymal stem cells extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	acute kidney injury mesenchymal stem cells extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999 Pei-Wen Lee Bo-Sheng Wu Chih-Yu Yang Oscar Kuang-Sheng Lee Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury
description	Acute kidney injury (AKI) causes a lot of harm to human health but is treated by only supportive therapy in most cases. Recent evidence shows that mesenchymal stem cells (MSCs) benefit kidney regeneration through releasing paracrine factors and extracellular vesicles (EVs) to the recipient kidney cells and are considered to be promising cellular therapy for AKI. To develop more efficient, precise therapies for AKI, we review the therapeutic mechanism of MSCs and MSC-derived EVs in AKI and look for a better understanding of molecular signaling and cellular communication between donor MSCs and recipient kidney cells. We also review recent clinical trials of MSC-EVs in AKI. This review summarizes the molecular mechanisms of MSCs’ therapeutic effects on kidney regeneration, expecting to comprehensively facilitate future clinical application for treating AKI.
format	article
author	Pei-Wen Lee Bo-Sheng Wu Chih-Yu Yang Oscar Kuang-Sheng Lee
author_facet	Pei-Wen Lee Bo-Sheng Wu Chih-Yu Yang Oscar Kuang-Sheng Lee
author_sort	Pei-Wen Lee
title	Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury
title_short	Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury
title_full	Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury
title_fullStr	Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury
title_full_unstemmed	Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury
title_sort	molecular mechanisms of mesenchymal stem cell-based therapy in acute kidney injury
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/12bd90d7e5c54f7d92ec637504c44e8f
work_keys_str_mv	AT peiwenlee molecularmechanismsofmesenchymalstemcellbasedtherapyinacutekidneyinjury AT boshengwu molecularmechanismsofmesenchymalstemcellbasedtherapyinacutekidneyinjury AT chihyuyang molecularmechanismsofmesenchymalstemcellbasedtherapyinacutekidneyinjury AT oscarkuangshenglee molecularmechanismsofmesenchymalstemcellbasedtherapyinacutekidneyinjury
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Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

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