Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen

The purpose of this study was to evaluate central and parafoveal inner retinal layer thickness in patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD). Participants underwent comprehensive ophthalmoscopic examination. Evidence of SDD or CD was evaluated with near infrared re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Solmaz Abdolrahimzadeh, Mariachiara Di Pippo, Edoardo Sordi, Sandrine Anne Zweifel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	subretinal drusenoid deposits reticular pseudodrusen conventional drusen age related macular degeneration inner retina Medicine R
Acceso en línea:	https://doaj.org/article/12bda96ab16646a6bb24be61b91f65f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:12bda96ab16646a6bb24be61b91f65f1
record_format	dspace
spelling	oai:doaj.org-article:12bda96ab16646a6bb24be61b91f65f12021-11-11T17:45:28ZInner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen10.3390/jcm102151362077-0383https://doaj.org/article/12bda96ab16646a6bb24be61b91f65f12021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5136https://doaj.org/toc/2077-0383The purpose of this study was to evaluate central and parafoveal inner retinal layer thickness in patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD). Participants underwent comprehensive ophthalmoscopic examination. Evidence of SDD or CD was evaluated with near infrared reflectance and spectral domain optical coherence tomography. Quantification of subfoveal lesions was made through a qualitative analysis of vertical and horizontal SD-OCT scans centered on the fovea. Inner retinal layer macular thickness measurements were obtained for central circles with 1, 3, and 5 mm diameter. Continuous variables were compared by the analysis of covariance (ANCOVA) with post-hoc Tukey HSD correction for multiple comparison analysis. Fifty-five patients were included in the study; 18 eyes with SDD alone, 19 eyes with CD alone, and 18 eyes of healthy age-matched subjects. Eight eyes with SDD (44%) and 13 eyes with CD (68%) had subfoveal lesions. There was significant reduction in the inner retinal layer thickness in the central 1mm area and in the superior 3 mm area in the SDD and CD group compared to controls. In conclusion the inner retinal layer is thinner in the central macula and in the superior parafovea in eyes.Solmaz AbdolrahimzadehMariachiara Di PippoEdoardo SordiSandrine Anne ZweifelMDPI AGarticlesubretinal drusenoid depositsreticular pseudodrusenconventional drusenage related macular degenerationinner retinaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5136, p 5136 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	subretinal drusenoid deposits reticular pseudodrusen conventional drusen age related macular degeneration inner retina Medicine R
spellingShingle	subretinal drusenoid deposits reticular pseudodrusen conventional drusen age related macular degeneration inner retina Medicine R Solmaz Abdolrahimzadeh Mariachiara Di Pippo Edoardo Sordi Sandrine Anne Zweifel Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen
description	The purpose of this study was to evaluate central and parafoveal inner retinal layer thickness in patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD). Participants underwent comprehensive ophthalmoscopic examination. Evidence of SDD or CD was evaluated with near infrared reflectance and spectral domain optical coherence tomography. Quantification of subfoveal lesions was made through a qualitative analysis of vertical and horizontal SD-OCT scans centered on the fovea. Inner retinal layer macular thickness measurements were obtained for central circles with 1, 3, and 5 mm diameter. Continuous variables were compared by the analysis of covariance (ANCOVA) with post-hoc Tukey HSD correction for multiple comparison analysis. Fifty-five patients were included in the study; 18 eyes with SDD alone, 19 eyes with CD alone, and 18 eyes of healthy age-matched subjects. Eight eyes with SDD (44%) and 13 eyes with CD (68%) had subfoveal lesions. There was significant reduction in the inner retinal layer thickness in the central 1mm area and in the superior 3 mm area in the SDD and CD group compared to controls. In conclusion the inner retinal layer is thinner in the central macula and in the superior parafovea in eyes.
format	article
author	Solmaz Abdolrahimzadeh Mariachiara Di Pippo Edoardo Sordi Sandrine Anne Zweifel
author_facet	Solmaz Abdolrahimzadeh Mariachiara Di Pippo Edoardo Sordi Sandrine Anne Zweifel
author_sort	Solmaz Abdolrahimzadeh
title	Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen
title_short	Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen
title_full	Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen
title_fullStr	Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen
title_full_unstemmed	Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen
title_sort	inner retinal layer thickness alterations in early age related macular degeneration in eyes with subretinal drusenoid deposits or conventional drusen
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/12bda96ab16646a6bb24be61b91f65f1
work_keys_str_mv	AT solmazabdolrahimzadeh innerretinallayerthicknessalterationsinearlyagerelatedmaculardegenerationineyeswithsubretinaldrusenoiddepositsorconventionaldrusen AT mariachiaradipippo innerretinallayerthicknessalterationsinearlyagerelatedmaculardegenerationineyeswithsubretinaldrusenoiddepositsorconventionaldrusen AT edoardosordi innerretinallayerthicknessalterationsinearlyagerelatedmaculardegenerationineyeswithsubretinaldrusenoiddepositsorconventionaldrusen AT sandrineannezweifel innerretinallayerthicknessalterationsinearlyagerelatedmaculardegenerationineyeswithsubretinaldrusenoiddepositsorconventionaldrusen
_version_	1718431986424479744

Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen

Ejemplares similares