SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN

We have measured total levels of alpha-2-macroglobulin (α2-MG), its immune complexes with IgG (α2-MG-IgG), along with IL-6, IL-8, IL-10, TNFα, lactoferrin (LF) and alpha-1-antitrypsin (AT) contents in blood sera of children with verified chronic adenoiditis (ChA), pharyngeal tonsil hypertrophy (PhTH...

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Autores principales:	V. N. Zorina, I. I. Klimova, A. C. Vyshlova, R. M. Zorina, T. G. Riabicheva, N. A. Zorin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	adenoiditis pharyngeal tonsil inflammation cytokines acute phase proteins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/12c3e84a4ac54f879f63146733c6be27
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spelling	oai:doaj.org-article:12c3e84a4ac54f879f63146733c6be272021-11-18T08:03:41ZSOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN1563-06252313-741X10.15789/1563-0625-2010-4-5-441-446https://doaj.org/article/12c3e84a4ac54f879f63146733c6be272014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/406https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have measured total levels of alpha-2-macroglobulin (α2-MG), its immune complexes with IgG (α2-MG-IgG), along with IL-6, IL-8, IL-10, TNFα, lactoferrin (LF) and alpha-1-antitrypsin (AT) contents in blood sera of children with verified chronic adenoiditis (ChA), pharyngeal tonsil hypertrophy (PhTH), and in sera of healthy children. It was shown, that α2-MG, α2-MG-IgG, AT, IL-10 serum concentrations in ChA and PhTH were significantly increased in comparison with appropriate values in healthy children. Moreover, we have detected significant increase in LF, and slight decrease of IL-6 and IL-8 contents in sera of ChA patients. All general trends of detected changes were similar for both diseases, but some changes proved to be differently expressed. In ChA, however, we found higher levels of circulating α2-MG molecules in circulation, some deficiency in IL-6 and IL-8, and significant abundance of IL-10 and LF at the beginning of ChA, thus resulting into a chronic disorder. In PhTH patients, there was no such remarkable abundance of α2-MG and LF in circulation, and no deficiency in IL-6 and IL-8, but higher levels of damaged α2-MG molecules complexing with IgG, total α2-MG, AT and IL-10 excess may provoke distinct metabolic changes and compensatory proliferation of tissues in this disorder.V. N. ZorinaI. I. KlimovaA. C. VyshlovaR. M. ZorinaT. G. RiabichevaN. A. ZorinSPb RAACIarticleadenoiditispharyngeal tonsilinflammationcytokinesacute phase proteinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 441-446 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	adenoiditis pharyngeal tonsil inflammation cytokines acute phase proteins Immunologic diseases. Allergy RC581-607
spellingShingle	adenoiditis pharyngeal tonsil inflammation cytokines acute phase proteins Immunologic diseases. Allergy RC581-607 V. N. Zorina I. I. Klimova A. C. Vyshlova R. M. Zorina T. G. Riabicheva N. A. Zorin SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN
description	We have measured total levels of alpha-2-macroglobulin (α2-MG), its immune complexes with IgG (α2-MG-IgG), along with IL-6, IL-8, IL-10, TNFα, lactoferrin (LF) and alpha-1-antitrypsin (AT) contents in blood sera of children with verified chronic adenoiditis (ChA), pharyngeal tonsil hypertrophy (PhTH), and in sera of healthy children. It was shown, that α2-MG, α2-MG-IgG, AT, IL-10 serum concentrations in ChA and PhTH were significantly increased in comparison with appropriate values in healthy children. Moreover, we have detected significant increase in LF, and slight decrease of IL-6 and IL-8 contents in sera of ChA patients. All general trends of detected changes were similar for both diseases, but some changes proved to be differently expressed. In ChA, however, we found higher levels of circulating α2-MG molecules in circulation, some deficiency in IL-6 and IL-8, and significant abundance of IL-10 and LF at the beginning of ChA, thus resulting into a chronic disorder. In PhTH patients, there was no such remarkable abundance of α2-MG and LF in circulation, and no deficiency in IL-6 and IL-8, but higher levels of damaged α2-MG molecules complexing with IgG, total α2-MG, AT and IL-10 excess may provoke distinct metabolic changes and compensatory proliferation of tissues in this disorder.
format	article
author	V. N. Zorina I. I. Klimova A. C. Vyshlova R. M. Zorina T. G. Riabicheva N. A. Zorin
author_facet	V. N. Zorina I. I. Klimova A. C. Vyshlova R. M. Zorina T. G. Riabicheva N. A. Zorin
author_sort	V. N. Zorina
title	SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN
title_short	SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN
title_full	SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN
title_fullStr	SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN
title_full_unstemmed	SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN
title_sort	some pathogenetic aspects of hyperthrophy and inflammation of pharyngeal tonsils in children
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/12c3e84a4ac54f879f63146733c6be27
work_keys_str_mv	AT vnzorina somepathogeneticaspectsofhyperthrophyandinflammationofpharyngealtonsilsinchildren AT iiklimova somepathogeneticaspectsofhyperthrophyandinflammationofpharyngealtonsilsinchildren AT acvyshlova somepathogeneticaspectsofhyperthrophyandinflammationofpharyngealtonsilsinchildren AT rmzorina somepathogeneticaspectsofhyperthrophyandinflammationofpharyngealtonsilsinchildren AT tgriabicheva somepathogeneticaspectsofhyperthrophyandinflammationofpharyngealtonsilsinchildren AT nazorin somepathogeneticaspectsofhyperthrophyandinflammationofpharyngealtonsilsinchildren
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SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN

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