Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lorena García-Hevia, Íñigo Casafont, Jessica Oliveira, Nuria Terán, Mónica L. Fanarraga, Juan Gallo, Manuel Bañobre-López
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/12c70d1f7be24829bfd33729f02a5f80
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:12c70d1f7be24829bfd33729f02a5f80
record_format	dspace
spelling	oai:doaj.org-article:12c70d1f7be24829bfd33729f02a5f802021-11-04T04:35:09ZMagnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics2452-199X10.1016/j.bioactmat.2021.06.009https://doaj.org/article/12c70d1f7be24829bfd33729f02a5f802022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21002930https://doaj.org/toc/2452-199XNowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications. Herein, a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient, green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug (doxorubicin) into a natural nano-matrix. The theranostic performance of the final magnetic formulation was validated in vitro and in vivo, in melanoma tumors. The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy, together with MRI reporting capability. The application of an alternating magnetic field was found to play a dual role, (i) acting as an extra layer of control (remote, on-demand) over the chemotherapy release and (ii) inducing a local thermal ablation of tumor cells. This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes, which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.Lorena García-HeviaÍñigo CasafontJessica OliveiraNuria TeránMónica L. FanarragaJuan GalloManuel Bañobre-LópezKeAi Communications Co., Ltd.articleDrug delivery systemsTheranosisMagnetic hyperthermiaMagnetic resonance imagingMelanomaMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 153-164 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Lorena García-Hevia Íñigo Casafont Jessica Oliveira Nuria Terán Mónica L. Fanarraga Juan Gallo Manuel Bañobre-López Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
description	Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications. Herein, a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient, green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug (doxorubicin) into a natural nano-matrix. The theranostic performance of the final magnetic formulation was validated in vitro and in vivo, in melanoma tumors. The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy, together with MRI reporting capability. The application of an alternating magnetic field was found to play a dual role, (i) acting as an extra layer of control (remote, on-demand) over the chemotherapy release and (ii) inducing a local thermal ablation of tumor cells. This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes, which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.
format	article
author	Lorena García-Hevia Íñigo Casafont Jessica Oliveira Nuria Terán Mónica L. Fanarraga Juan Gallo Manuel Bañobre-López
author_facet	Lorena García-Hevia Íñigo Casafont Jessica Oliveira Nuria Terán Mónica L. Fanarraga Juan Gallo Manuel Bañobre-López
author_sort	Lorena García-Hevia
title	Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
title_short	Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
title_full	Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
title_fullStr	Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
title_full_unstemmed	Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
title_sort	magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by mri for melanoma theranostics
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/12c70d1f7be24829bfd33729f02a5f80
work_keys_str_mv	AT lorenagarciahevia magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics AT inigocasafont magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics AT jessicaoliveira magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics AT nuriateran magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics AT monicalfanarraga magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics AT juangallo magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics AT manuelbanobrelopez magneticlipidnanovehiclessynergizethecontrolledthermalreleaseofchemotherapeuticswithmagneticablationwhileenablingnoninvasivemonitoringbymriformelanomatheranostics
_version_	1718445254935314432

Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

Ejemplares similares