TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension

TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension

Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that interference with the activation process prevents disea...

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Autores principales: Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffrey C. Robinson, Daniel E. Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Alexandre McKeon, Suzette Riddle, R. Dale Brown, Leslie E. Morgan, Christopher M. Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James P. Maloney, Todd M. Bull, William J. Janssen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a
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spelling oai:doaj.org-article:12cae9f76300462c9772bdd1e67bd44a2021-12-02T16:51:42ZTGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension10.1038/ncomms154942041-1723https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15494https://doaj.org/toc/2041-1723Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that interference with the activation process prevents disease development.Rahul KumarClaudia MickaelBiruk KassaLiya GebreabJeffrey C. RobinsonDaniel E. KoyanagiLinda SandersLea BarthelChristina MeadowsDaniel FoxDavid IrwinMin LiB. Alexandre McKeonSuzette RiddleR. Dale BrownLeslie E. MorganChristopher M. EvansDaniel Hernandez-SaavedraAngela BandeiraJames P. MaloneyTodd M. BullWilliam J. JanssenKurt R. StenmarkRubin M. TuderBrian B. GrahamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rahul Kumar
Claudia Mickael
Biruk Kassa
Liya Gebreab
Jeffrey C. Robinson
Daniel E. Koyanagi
Linda Sanders
Lea Barthel
Christina Meadows
Daniel Fox
David Irwin
Min Li
B. Alexandre McKeon
Suzette Riddle
R. Dale Brown
Leslie E. Morgan
Christopher M. Evans
Daniel Hernandez-Saavedra
Angela Bandeira
James P. Maloney
Todd M. Bull
William J. Janssen
Kurt R. Stenmark
Rubin M. Tuder
Brian B. Graham
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
description Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that interference with the activation process prevents disease development.
format article
author Rahul Kumar
Claudia Mickael
Biruk Kassa
Liya Gebreab
Jeffrey C. Robinson
Daniel E. Koyanagi
Linda Sanders
Lea Barthel
Christina Meadows
Daniel Fox
David Irwin
Min Li
B. Alexandre McKeon
Suzette Riddle
R. Dale Brown
Leslie E. Morgan
Christopher M. Evans
Daniel Hernandez-Saavedra
Angela Bandeira
James P. Maloney
Todd M. Bull
William J. Janssen
Kurt R. Stenmark
Rubin M. Tuder
Brian B. Graham
author_facet Rahul Kumar
Claudia Mickael
Biruk Kassa
Liya Gebreab
Jeffrey C. Robinson
Daniel E. Koyanagi
Linda Sanders
Lea Barthel
Christina Meadows
Daniel Fox
David Irwin
Min Li
B. Alexandre McKeon
Suzette Riddle
R. Dale Brown
Leslie E. Morgan
Christopher M. Evans
Daniel Hernandez-Saavedra
Angela Bandeira
James P. Maloney
Todd M. Bull
William J. Janssen
Kurt R. Stenmark
Rubin M. Tuder
Brian B. Graham
author_sort Rahul Kumar
title TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
title_short TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
title_full TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
title_fullStr TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
title_full_unstemmed TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
title_sort tgf-β activation by bone marrow-derived thrombospondin-1 causes schistosoma- and hypoxia-induced pulmonary hypertension
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/12cae9f76300462c9772bdd1e67bd44a
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