Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years

Abstract The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cog...

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Autores principales:	Bernhard W. Müller, Anke Hinney, Norbert Scherbaum, Christian Weimar, Christoph Kleinschnitz, Triinu Peters, Lara Hochfeld, Sonali Pechlivanis, Andreas Stang, Martha Jokisch, Bernd Kowall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/12cc7536aa674c459fb106c25f293506
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spelling	oai:doaj.org-article:12cc7536aa674c459fb106c25f2935062021-12-02T18:34:13ZKlotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years10.1038/s41598-021-93211-x2045-2322https://doaj.org/article/12cc7536aa674c459fb106c25f2935062021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93211-xhttps://doaj.org/toc/2045-2322Abstract The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55–87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = − 0.042 (verbal fluency) and − 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI − 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55–65 years, 66–75 years, > 75 years). In the 66–75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study.Bernhard W. MüllerAnke HinneyNorbert ScherbaumChristian WeimarChristoph KleinschnitzTriinu PetersLara HochfeldSonali PechlivanisAndreas StangMartha JokischBernd KowallNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernhard W. Müller Anke Hinney Norbert Scherbaum Christian Weimar Christoph Kleinschnitz Triinu Peters Lara Hochfeld Sonali Pechlivanis Andreas Stang Martha Jokisch Bernd Kowall Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
description	Abstract The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55–87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = − 0.042 (verbal fluency) and − 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI − 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55–65 years, 66–75 years, > 75 years). In the 66–75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study.
format	article
author	Bernhard W. Müller Anke Hinney Norbert Scherbaum Christian Weimar Christoph Kleinschnitz Triinu Peters Lara Hochfeld Sonali Pechlivanis Andreas Stang Martha Jokisch Bernd Kowall
author_facet	Bernhard W. Müller Anke Hinney Norbert Scherbaum Christian Weimar Christoph Kleinschnitz Triinu Peters Lara Hochfeld Sonali Pechlivanis Andreas Stang Martha Jokisch Bernd Kowall
author_sort	Bernhard W. Müller
title	Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
title_short	Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
title_full	Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
title_fullStr	Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
title_full_unstemmed	Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
title_sort	klotho kl-vs haplotype does not improve cognition in a population-based sample of adults age 55–87 years
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12cc7536aa674c459fb106c25f293506
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Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years

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