Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
Qi Li,1 Suna Cai,1 Mengjiao Li,1 Kab Ibrahim Salma,1 Xiaojie Zhou,1 Feiyu Han,2 Jinzhao Chen,2 Ting Huyan1,3 1Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s R...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Acceso en línea: | https://doaj.org/article/12cf4cc341f6431cb3e92803d1733e04 |
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| Sumario: | Qi Li,1 Suna Cai,1 Mengjiao Li,1 Kab Ibrahim Salma,1 Xiaojie Zhou,1 Feiyu Han,2 Jinzhao Chen,2 Ting Huyan1,3 1Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2Shanxi Weiqidaguangming Pharmaceutical Co., Ltd, The First Medical Park, Economic & Technology Development Zone, Datong, 037000, People’s Republic of China; 3Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Ting HuyanKey Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of ChinaTel/Fax +86 29 8846 0332Email huyanting@nwpu.edu.cnAbstract: Nowadays, tumor has been the serious threat to human health and life. To further explore the mechanism of tumor genesis and development is necessarily for developing the effective treatment strategy. Extracellular vesicles are the vesicles secreted by almost all types of cells, and they play an important part in intercellular communication by transporting their cargoes. Immune cells are the vital components of the human defense system, which defense against infection and tumor through cytotoxicity, immune surveillance, and clearance. However, via release tumor-derived extracellular vesicles, tumor could induce immune cells dysfunction to facilitate its proliferation and metastasis. Studies have shown that tumor-derived extracellular vesicles play dual role on immune cells by their specific cargoes. Here, we reviewed the effects of tumor-derived extracellular vesicles on immune cells in recent years and also summarized their research progress in the tumor immunotherapy and diagnosis.Keywords: tumor-derived extracellular vesicles, immune cell, regulatory effects, drug delivery, immunotherapy |
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