Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy

Qi Li,1 Suna Cai,1 Mengjiao Li,1 Kab Ibrahim Salma,1 Xiaojie Zhou,1 Feiyu Han,2 Jinzhao Chen,2 Ting Huyan1,3 1Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s R...

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Autores principales:	Li Q, Cai S, Li M, Salma KI, Zhou X, Han F, Chen J, Huyan T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	tumor-derived extracellular vesicles immune cell regulatory effects drug delivery immunotherapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/12cf4cc341f6431cb3e92803d1733e04
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spelling	oai:doaj.org-article:12cf4cc341f6431cb3e92803d1733e042021-12-02T16:39:49ZTumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy1178-2013https://doaj.org/article/12cf4cc341f6431cb3e92803d1733e042021-08-01T00:00:00Zhttps://www.dovepress.com/tumor-derived-extracellular-vesicles-their-role-in-immune-cells-and-im-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Qi Li,1 Suna Cai,1 Mengjiao Li,1 Kab Ibrahim Salma,1 Xiaojie Zhou,1 Feiyu Han,2 Jinzhao Chen,2 Ting Huyan1,3 1Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2Shanxi Weiqidaguangming Pharmaceutical Co., Ltd, The First Medical Park, Economic & Technology Development Zone, Datong, 037000, People’s Republic of China; 3Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Ting HuyanKey Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of ChinaTel/Fax +86 29 8846 0332Email huyanting@nwpu.edu.cnAbstract: Nowadays, tumor has been the serious threat to human health and life. To further explore the mechanism of tumor genesis and development is necessarily for developing the effective treatment strategy. Extracellular vesicles are the vesicles secreted by almost all types of cells, and they play an important part in intercellular communication by transporting their cargoes. Immune cells are the vital components of the human defense system, which defense against infection and tumor through cytotoxicity, immune surveillance, and clearance. However, via release tumor-derived extracellular vesicles, tumor could induce immune cells dysfunction to facilitate its proliferation and metastasis. Studies have shown that tumor-derived extracellular vesicles play dual role on immune cells by their specific cargoes. Here, we reviewed the effects of tumor-derived extracellular vesicles on immune cells in recent years and also summarized their research progress in the tumor immunotherapy and diagnosis.Keywords: tumor-derived extracellular vesicles, immune cell, regulatory effects, drug delivery, immunotherapyLi QCai SLi MSalma KIZhou XHan FChen JHuyan TDove Medical Pressarticletumor-derived extracellular vesiclesimmune cellregulatory effectsdrug deliveryimmunotherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 5395-5409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor-derived extracellular vesicles immune cell regulatory effects drug delivery immunotherapy Medicine (General) R5-920
spellingShingle	tumor-derived extracellular vesicles immune cell regulatory effects drug delivery immunotherapy Medicine (General) R5-920 Li Q Cai S Li M Salma KI Zhou X Han F Chen J Huyan T Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
description	Qi Li,1 Suna Cai,1 Mengjiao Li,1 Kab Ibrahim Salma,1 Xiaojie Zhou,1 Feiyu Han,2 Jinzhao Chen,2 Ting Huyan1,3 1Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2Shanxi Weiqidaguangming Pharmaceutical Co., Ltd, The First Medical Park, Economic & Technology Development Zone, Datong, 037000, People’s Republic of China; 3Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Ting HuyanKey Laboratory for Space Biosciences and Biotechnology, Institute of Special Environment Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of ChinaTel/Fax +86 29 8846 0332Email huyanting@nwpu.edu.cnAbstract: Nowadays, tumor has been the serious threat to human health and life. To further explore the mechanism of tumor genesis and development is necessarily for developing the effective treatment strategy. Extracellular vesicles are the vesicles secreted by almost all types of cells, and they play an important part in intercellular communication by transporting their cargoes. Immune cells are the vital components of the human defense system, which defense against infection and tumor through cytotoxicity, immune surveillance, and clearance. However, via release tumor-derived extracellular vesicles, tumor could induce immune cells dysfunction to facilitate its proliferation and metastasis. Studies have shown that tumor-derived extracellular vesicles play dual role on immune cells by their specific cargoes. Here, we reviewed the effects of tumor-derived extracellular vesicles on immune cells in recent years and also summarized their research progress in the tumor immunotherapy and diagnosis.Keywords: tumor-derived extracellular vesicles, immune cell, regulatory effects, drug delivery, immunotherapy
format	article
author	Li Q Cai S Li M Salma KI Zhou X Han F Chen J Huyan T
author_facet	Li Q Cai S Li M Salma KI Zhou X Han F Chen J Huyan T
author_sort	Li Q
title	Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
title_short	Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
title_full	Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
title_fullStr	Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
title_full_unstemmed	Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy
title_sort	tumor-derived extracellular vesicles: their role in immune cells and immunotherapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/12cf4cc341f6431cb3e92803d1733e04
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Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy

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