Possible Association of Cholesterol as a Biomarker in Suicide Behavior

Suicides and suicidal behavior are major causes of mortality and morbidity in public health and are a global problem. Various authors have proposed changes in lipid metabolism (total cholesterol decrease) as a possible biological marker for suicidal behavior. The objective of this study was to revie...

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Autores principales:	Thelma Beatriz González-Castro, Alma Delia Genis-Mendoza, Dulce Ivannia León-Escalante, Yazmín Hernández-Díaz, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zárate, María Lilia López-Narváez, Alejandro Marín-Medina, Humberto Nicolini, Rosa Giannina Castillo-Avila, Miguel Ángel Ramos-Méndez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psychiatric illnesses suicide cholesterol serum Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/12d15a25a34749f4ab2b86f39b5e097e
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spelling	oai:doaj.org-article:12d15a25a34749f4ab2b86f39b5e097e2021-11-25T16:49:00ZPossible Association of Cholesterol as a Biomarker in Suicide Behavior10.3390/biomedicines91115592227-9059https://doaj.org/article/12d15a25a34749f4ab2b86f39b5e097e2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1559https://doaj.org/toc/2227-9059Suicides and suicidal behavior are major causes of mortality and morbidity in public health and are a global problem. Various authors have proposed changes in lipid metabolism (total cholesterol decrease) as a possible biological marker for suicidal behavior. The objective of this study was to review the studies that have demonstrated a relationship between serum cholesterol levels and suicidal behavior and to describe the possible pathophysiological mechanisms that associate changes in cholesterol concentration and suicidal behavior. Relevant literature related to serum cholesterol levels and suicidal behavior was identified through various database searches. The data from the existing literature present the findings that relate low cholesterol levels and possible pathophysiological mechanisms (neuroinflammation, serotonergic neurotransmission), genes related to cholesterol synthesis, pharmacological treatments that alter lipid metabolism and the possible participation in suicidal behavior. Nevertheless, future research is required to describe how serum cholesterol affects cholesterol metabolism in the CNS to establish and understand the role of cholesterol in suicidal behavior.Thelma Beatriz González-CastroAlma Delia Genis-MendozaDulce Ivannia León-EscalanteYazmín Hernández-DíazIsela Esther Juárez-RojopCarlos Alfonso Tovilla-ZárateMaría Lilia López-NarváezAlejandro Marín-MedinaHumberto NicoliniRosa Giannina Castillo-AvilaMiguel Ángel Ramos-MéndezMDPI AGarticlepsychiatric illnessessuicidecholesterolserumBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1559, p 1559 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psychiatric illnesses suicide cholesterol serum Biology (General) QH301-705.5
spellingShingle	psychiatric illnesses suicide cholesterol serum Biology (General) QH301-705.5 Thelma Beatriz González-Castro Alma Delia Genis-Mendoza Dulce Ivannia León-Escalante Yazmín Hernández-Díaz Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zárate María Lilia López-Narváez Alejandro Marín-Medina Humberto Nicolini Rosa Giannina Castillo-Avila Miguel Ángel Ramos-Méndez Possible Association of Cholesterol as a Biomarker in Suicide Behavior
description	Suicides and suicidal behavior are major causes of mortality and morbidity in public health and are a global problem. Various authors have proposed changes in lipid metabolism (total cholesterol decrease) as a possible biological marker for suicidal behavior. The objective of this study was to review the studies that have demonstrated a relationship between serum cholesterol levels and suicidal behavior and to describe the possible pathophysiological mechanisms that associate changes in cholesterol concentration and suicidal behavior. Relevant literature related to serum cholesterol levels and suicidal behavior was identified through various database searches. The data from the existing literature present the findings that relate low cholesterol levels and possible pathophysiological mechanisms (neuroinflammation, serotonergic neurotransmission), genes related to cholesterol synthesis, pharmacological treatments that alter lipid metabolism and the possible participation in suicidal behavior. Nevertheless, future research is required to describe how serum cholesterol affects cholesterol metabolism in the CNS to establish and understand the role of cholesterol in suicidal behavior.
format	article
author	Thelma Beatriz González-Castro Alma Delia Genis-Mendoza Dulce Ivannia León-Escalante Yazmín Hernández-Díaz Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zárate María Lilia López-Narváez Alejandro Marín-Medina Humberto Nicolini Rosa Giannina Castillo-Avila Miguel Ángel Ramos-Méndez
author_facet	Thelma Beatriz González-Castro Alma Delia Genis-Mendoza Dulce Ivannia León-Escalante Yazmín Hernández-Díaz Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zárate María Lilia López-Narváez Alejandro Marín-Medina Humberto Nicolini Rosa Giannina Castillo-Avila Miguel Ángel Ramos-Méndez
author_sort	Thelma Beatriz González-Castro
title	Possible Association of Cholesterol as a Biomarker in Suicide Behavior
title_short	Possible Association of Cholesterol as a Biomarker in Suicide Behavior
title_full	Possible Association of Cholesterol as a Biomarker in Suicide Behavior
title_fullStr	Possible Association of Cholesterol as a Biomarker in Suicide Behavior
title_full_unstemmed	Possible Association of Cholesterol as a Biomarker in Suicide Behavior
title_sort	possible association of cholesterol as a biomarker in suicide behavior
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/12d15a25a34749f4ab2b86f39b5e097e
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_version_	1718412940403539968

Possible Association of Cholesterol as a Biomarker in Suicide Behavior

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