Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

Antibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct intera...

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Autores principales:	Avia Watson, Hao Li, Bingting Ma, Ronen Weiss, Daniele Bendayan, Lilach Abramovitz, Noam Ben-Shalom, Michael Mor, Erica Pinko, Michal Bar Oz, Zhenqi Wang, Fengjiao Du, Yu Lu, Jan Rybniker, Rony Dahan, Hairong Huang, Daniel Barkan, Ye Xiang, Babak Javid, Natalia T. Freund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12d17b4408464c90aef7ffb8954e3827
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spelling	oai:doaj.org-article:12d17b4408464c90aef7ffb8954e38272021-12-02T14:16:14ZHuman antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis10.1038/s41467-021-20930-02041-1723https://doaj.org/article/12d17b4408464c90aef7ffb8954e38272021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20930-0https://doaj.org/toc/2041-1723Antibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct interaction modes in crystal structure, and mediate protection in vitro.Avia WatsonHao LiBingting MaRonen WeissDaniele BendayanLilach AbramovitzNoam Ben-ShalomMichael MorErica PinkoMichal Bar OzZhenqi WangFengjiao DuYu LuJan RybnikerRony DahanHairong HuangDaniel BarkanYe XiangBabak JavidNatalia T. FreundNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Avia Watson Hao Li Bingting Ma Ronen Weiss Daniele Bendayan Lilach Abramovitz Noam Ben-Shalom Michael Mor Erica Pinko Michal Bar Oz Zhenqi Wang Fengjiao Du Yu Lu Jan Rybniker Rony Dahan Hairong Huang Daniel Barkan Ye Xiang Babak Javid Natalia T. Freund Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
description	Antibody responses against Mycobacteria infection have been reported, but whether and how they impact anti-bacteria immunity in the host is unclear. Here the authors characterize human anti-Mycobacteria antibodies to find them targeting a Mycobacteria transporter protein, PstS1, show distinct interaction modes in crystal structure, and mediate protection in vitro.
format	article
author	Avia Watson Hao Li Bingting Ma Ronen Weiss Daniele Bendayan Lilach Abramovitz Noam Ben-Shalom Michael Mor Erica Pinko Michal Bar Oz Zhenqi Wang Fengjiao Du Yu Lu Jan Rybniker Rony Dahan Hairong Huang Daniel Barkan Ye Xiang Babak Javid Natalia T. Freund
author_facet	Avia Watson Hao Li Bingting Ma Ronen Weiss Daniele Bendayan Lilach Abramovitz Noam Ben-Shalom Michael Mor Erica Pinko Michal Bar Oz Zhenqi Wang Fengjiao Du Yu Lu Jan Rybniker Rony Dahan Hairong Huang Daniel Barkan Ye Xiang Babak Javid Natalia T. Freund
author_sort	Avia Watson
title	Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
title_short	Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
title_full	Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
title_fullStr	Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
title_full_unstemmed	Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
title_sort	human antibodies targeting a mycobacterium transporter protein mediate protection against tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12d17b4408464c90aef7ffb8954e3827
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Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

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