Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functio...
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Nature Portfolio
2018
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oai:doaj.org-article:12d27a6322604934916857f1fe60bd7c2021-12-02T15:33:45ZComplement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism10.1038/s41467-018-06706-z2041-1723https://doaj.org/article/12d27a6322604934916857f1fe60bd7c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06706-zhttps://doaj.org/toc/2041-1723Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells.Giuseppina ArboreErin E. WestJubayer RahmanGaelle Le FriecNathalie NiyonzimaMehdi PiroozniaIlker TuncPolychronis PavlidisNicholas PowellYuesheng LiPoching LiuAude ServaisLionel CouziVeronique Fremeaux-BacchiLeo PlacaisAlastair FerraroPatrick R. WalshDavid KavanaghBehdad AfzaliPaul LavenderHelen J. LachmannClaudia KemperNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Giuseppina Arbore Erin E. West Jubayer Rahman Gaelle Le Friec Nathalie Niyonzima Mehdi Pirooznia Ilker Tunc Polychronis Pavlidis Nicholas Powell Yuesheng Li Poching Liu Aude Servais Lionel Couzi Veronique Fremeaux-Bacchi Leo Placais Alastair Ferraro Patrick R. Walsh David Kavanagh Behdad Afzali Paul Lavender Helen J. Lachmann Claudia Kemper Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism |
| description |
Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells. |
| format |
article |
| author |
Giuseppina Arbore Erin E. West Jubayer Rahman Gaelle Le Friec Nathalie Niyonzima Mehdi Pirooznia Ilker Tunc Polychronis Pavlidis Nicholas Powell Yuesheng Li Poching Liu Aude Servais Lionel Couzi Veronique Fremeaux-Bacchi Leo Placais Alastair Ferraro Patrick R. Walsh David Kavanagh Behdad Afzali Paul Lavender Helen J. Lachmann Claudia Kemper |
| author_facet |
Giuseppina Arbore Erin E. West Jubayer Rahman Gaelle Le Friec Nathalie Niyonzima Mehdi Pirooznia Ilker Tunc Polychronis Pavlidis Nicholas Powell Yuesheng Li Poching Liu Aude Servais Lionel Couzi Veronique Fremeaux-Bacchi Leo Placais Alastair Ferraro Patrick R. Walsh David Kavanagh Behdad Afzali Paul Lavender Helen J. Lachmann Claudia Kemper |
| author_sort |
Giuseppina Arbore |
| title |
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism |
| title_short |
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism |
| title_full |
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism |
| title_fullStr |
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism |
| title_full_unstemmed |
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism |
| title_sort |
complement receptor cd46 co-stimulates optimal human cd8+ t cell effector function via fatty acid metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/12d27a6322604934916857f1fe60bd7c |
| work_keys_str_mv |
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| _version_ |
1718387005690216448 |