Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study

Paul Y Takahashi, Casey R Caldwell, Paul V TargonskiPrimary Care Internal Medicine, Mayo Clinic, Rochester MN, USABackground: Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascula...

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Autores principales:	Takahashi PY, Caldwell CR, Targonski PV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Polyvascular disease vascular dementia elderly case-controlled study Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/12dcef2005984348b989a7fed1e986d4
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spelling	oai:doaj.org-article:12dcef2005984348b989a7fed1e986d42021-12-02T00:39:05ZEffect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study1178-1998https://doaj.org/article/12dcef2005984348b989a7fed1e986d42012-01-01T00:00:00Zhttps://www.dovepress.com/effect-of-vascular-burden-as-measured-by-vascular-indexes-upon-vascula-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Paul Y Takahashi, Casey R Caldwell, Paul V TargonskiPrimary Care Internal Medicine, Mayo Clinic, Rochester MN, USABackground: Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD.Purpose: To determine the relationship between multiple vascular risk exposures, as counted on an index in cases with VaD, compared with healthy age-/gender-matched controls.Methods: This was a matched case-control study of subjects living in Olmsted County, MN with documented VaD. Controls were selected by gender and age within 3 years from those who did not have dementia. The exposures included a total index (eleven exposure factors) added together, along with indexes for cerebrovascular disease (two exposures), cardiovascular disease (four exposures), vascular disease (three exposures), and lifestyle (two exposures). Analysis used matched conditional univariable logistic regression for each index.Results: A total of 1736 potential subjects were identified, and 205 subjects were diagnosed with VaD. There was a significant association of the total score index with an odds ratio of 1.45 (95% confidence interval 1.21–1.74). The cerebrovascular index was also associated with VaD with an odds ratio of 12.18 (95% confidence interval 6.29–23.61). The cardiovascular and vascular indexes were also associated with VaD status. The lifestyle index was not associated with VaD.Conclusion: The cumulative role of multiple vascular risk factors or diseases increased the risk of VaD, as noted by the total vascular index. The lifestyle index did not reveal any significant differences. Further work is required for evaluation of these indexes.Keywords: polyvascular disease, elderly, vascular dementiaTakahashi PYCaldwell CRTargonski PVDove Medical PressarticlePolyvascular diseasevascular dementiaelderlycase-controlled studyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 7, Pp 27-33 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polyvascular disease vascular dementia elderly case-controlled study Geriatrics RC952-954.6
spellingShingle	Polyvascular disease vascular dementia elderly case-controlled study Geriatrics RC952-954.6 Takahashi PY Caldwell CR Targonski PV Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
description	Paul Y Takahashi, Casey R Caldwell, Paul V TargonskiPrimary Care Internal Medicine, Mayo Clinic, Rochester MN, USABackground: Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD.Purpose: To determine the relationship between multiple vascular risk exposures, as counted on an index in cases with VaD, compared with healthy age-/gender-matched controls.Methods: This was a matched case-control study of subjects living in Olmsted County, MN with documented VaD. Controls were selected by gender and age within 3 years from those who did not have dementia. The exposures included a total index (eleven exposure factors) added together, along with indexes for cerebrovascular disease (two exposures), cardiovascular disease (four exposures), vascular disease (three exposures), and lifestyle (two exposures). Analysis used matched conditional univariable logistic regression for each index.Results: A total of 1736 potential subjects were identified, and 205 subjects were diagnosed with VaD. There was a significant association of the total score index with an odds ratio of 1.45 (95% confidence interval 1.21–1.74). The cerebrovascular index was also associated with VaD with an odds ratio of 12.18 (95% confidence interval 6.29–23.61). The cardiovascular and vascular indexes were also associated with VaD status. The lifestyle index was not associated with VaD.Conclusion: The cumulative role of multiple vascular risk factors or diseases increased the risk of VaD, as noted by the total vascular index. The lifestyle index did not reveal any significant differences. Further work is required for evaluation of these indexes.Keywords: polyvascular disease, elderly, vascular dementia
format	article
author	Takahashi PY Caldwell CR Targonski PV
author_facet	Takahashi PY Caldwell CR Targonski PV
author_sort	Takahashi PY
title	Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
title_short	Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
title_full	Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
title_fullStr	Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
title_full_unstemmed	Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
title_sort	effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/12dcef2005984348b989a7fed1e986d4
work_keys_str_mv	AT takahashipy effectofvascularburdenasmeasuredbyvascularindexesuponvasculardementiaamatchedcasecontrolstudy AT caldwellcr effectofvascularburdenasmeasuredbyvascularindexesuponvasculardementiaamatchedcasecontrolstudy AT targonskipv effectofvascularburdenasmeasuredbyvascularindexesuponvasculardementiaamatchedcasecontrolstudy
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Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study

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