ER-Phagy and Microbial Infection

The endoplasmic reticulum (ER) is an essential organelle in cells that synthesizes, folds and modifies membrane and secretory proteins. It has a crucial role in cell survival and growth, thus requiring strict control of its quality and homeostasis. Autophagy of the ER fragments, termed ER-phagy or r...

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Autores principales:	Jiahui Li, Enfeng Gao, Chenguang Xu, Hongna Wang, Yongjie Wei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ER-phagy virus infection bacteria microbial reticulophagy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/12e1e90b5e0d49d39522ba8a32bedca9
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spelling	oai:doaj.org-article:12e1e90b5e0d49d39522ba8a32bedca92021-12-01T13:38:41ZER-Phagy and Microbial Infection2296-634X10.3389/fcell.2021.771353https://doaj.org/article/12e1e90b5e0d49d39522ba8a32bedca92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.771353/fullhttps://doaj.org/toc/2296-634XThe endoplasmic reticulum (ER) is an essential organelle in cells that synthesizes, folds and modifies membrane and secretory proteins. It has a crucial role in cell survival and growth, thus requiring strict control of its quality and homeostasis. Autophagy of the ER fragments, termed ER-phagy or reticulophagy, is an essential mechanism responsible for ER quality control. It transports stress-damaged ER fragments as cargo into the lysosome for degradation to eliminate unfolded or misfolded protein aggregates and membrane lipids. ER-phagy can also function as a host defense mechanism when pathogens infect cells, and its deficiency facilitates viral infection. This review briefly describes the process and regulatory mechanisms of ER-phagy, and its function in host anti-microbial defense during infection.Jiahui LiJiahui LiEnfeng GaoEnfeng GaoChenguang XuChenguang XuHongna WangHongna WangHongna WangYongjie WeiYongjie WeiYongjie WeiFrontiers Media S.A.articleER-phagyvirusinfectionbacteriamicrobialreticulophagyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ER-phagy virus infection bacteria microbial reticulophagy Biology (General) QH301-705.5
spellingShingle	ER-phagy virus infection bacteria microbial reticulophagy Biology (General) QH301-705.5 Jiahui Li Jiahui Li Enfeng Gao Enfeng Gao Chenguang Xu Chenguang Xu Hongna Wang Hongna Wang Hongna Wang Yongjie Wei Yongjie Wei Yongjie Wei ER-Phagy and Microbial Infection
description	The endoplasmic reticulum (ER) is an essential organelle in cells that synthesizes, folds and modifies membrane and secretory proteins. It has a crucial role in cell survival and growth, thus requiring strict control of its quality and homeostasis. Autophagy of the ER fragments, termed ER-phagy or reticulophagy, is an essential mechanism responsible for ER quality control. It transports stress-damaged ER fragments as cargo into the lysosome for degradation to eliminate unfolded or misfolded protein aggregates and membrane lipids. ER-phagy can also function as a host defense mechanism when pathogens infect cells, and its deficiency facilitates viral infection. This review briefly describes the process and regulatory mechanisms of ER-phagy, and its function in host anti-microbial defense during infection.
format	article
author	Jiahui Li Jiahui Li Enfeng Gao Enfeng Gao Chenguang Xu Chenguang Xu Hongna Wang Hongna Wang Hongna Wang Yongjie Wei Yongjie Wei Yongjie Wei
author_facet	Jiahui Li Jiahui Li Enfeng Gao Enfeng Gao Chenguang Xu Chenguang Xu Hongna Wang Hongna Wang Hongna Wang Yongjie Wei Yongjie Wei Yongjie Wei
author_sort	Jiahui Li
title	ER-Phagy and Microbial Infection
title_short	ER-Phagy and Microbial Infection
title_full	ER-Phagy and Microbial Infection
title_fullStr	ER-Phagy and Microbial Infection
title_full_unstemmed	ER-Phagy and Microbial Infection
title_sort	er-phagy and microbial infection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/12e1e90b5e0d49d39522ba8a32bedca9
work_keys_str_mv	AT jiahuili erphagyandmicrobialinfection AT jiahuili erphagyandmicrobialinfection AT enfenggao erphagyandmicrobialinfection AT enfenggao erphagyandmicrobialinfection AT chenguangxu erphagyandmicrobialinfection AT chenguangxu erphagyandmicrobialinfection AT hongnawang erphagyandmicrobialinfection AT hongnawang erphagyandmicrobialinfection AT hongnawang erphagyandmicrobialinfection AT yongjiewei erphagyandmicrobialinfection AT yongjiewei erphagyandmicrobialinfection AT yongjiewei erphagyandmicrobialinfection
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ER-Phagy and Microbial Infection

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