Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis

QR Code

Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis

Abstract Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl− channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the abundant expression of CFTR in mammalian kidney, the role of CFTR in kidney di...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Jie Ting Zhang, Yan Wang, Jun Jiang Chen, Xiao Hu Zhang, Jian Da Dong, Lai Ling Tsang, Xiao Ru Huang, Zhiming Cai, Hui Yao Lan, Xiao Hua Jiang, Hsiao Chang Chan
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/12e229d7fb814a3bb6c5e7916e428cd8
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/β-catenin signaling
par: Jiankun Xu, et autres
Publié: (2022)

Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis.
par: Claudio Sorio, et autres
Publié: (2011)

Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
par: Shen Li, et autres
Publié: (2021)

Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
par: Iwona M. Pranke, et autres
Publié: (2017)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
par: Chung-Ming Lin, et autres
Publié: (2017)

Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis
par: Maite Calucho, et autres
Publié: (2021)

Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
par: Fu-Li Xiang, et autres
Publié: (2017)

Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling.
par: Ting Ting Zhao, et autres
Publié: (2014)

CXCL14 facilitates the growth and metastasis of ovarian carcinoma cells via activation of the Wnt/β-catenin signaling pathway
par: Li-Na Gao, et autres
Publié: (2021)

Aberrant Upregulation of Indoleamine 2,3-Dioxygenase 1 Promotes Proliferation and Metastasis of Hepatocellular Carcinoma Cells via Coordinated Activation of AhR and β-Catenin Signaling
par: Chih-Ta Chen, et autres
Publié: (2021)

Activation of Wnt/β-catenin pathway in monocytes derived from chronic kidney disease patients.
par: Heevy Abdulkareem Musa Al-Chaqmaqchi, et autres
Publié: (2013)

CFTR mutations spectrum and the efficiency of molecular diagnostics in Polish cystic fibrosis patients.
par: Ewa Ziętkiewicz, et autres
Publié: (2014)

Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
par: Ke Zhu, et autres
Publié: (2020)

Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1.
par: Xiaobao Fan, et autres
Publié: (2013)

Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney DiseaseSummary
par: Murali K. Yanda, et autres
Publié: (2021)

Cystic fibrosis transmembrane conductance regulator (CFTR) allelic variants relate to shifts in faecal microbiota of cystic fibrosis patients.
par: Serena Schippa, et autres
Publié: (2013)

Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock
par: Ilandarage Menu Neelaka Molagoda, et autres
Publié: (2021)

Wnt-β Catenin Signaling Pathway: A Major Player in the Injury Induced Fibrosis and Dysfunction of the External Anal Sphincter
par: M. Raj Rajasekaran, et autres
Publié: (2017)

(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages
par: Chandra L. Shrestha, et autres
Publié: (2020)

Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
par: M. Chioccioli, et autres
Publié: (2019)

Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)
par: B. B. Stauffer, et autres
Publié: (2017)

Correction of chloride transport and mislocalization of CFTR protein by vardenafil in the gastrointestinal tract of cystic fibrosis mice.
par: Barbara Dhooghe, et autres
Publié: (2013)

P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.
par: Guiyang Jiang, et autres
Publié: (2012)

Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model
par: Yuko Tokunaga, et autres
Publié: (2017)

Cdc42 Promotes ADSC-Derived IPC Induction, Proliferation, And Insulin Secretion Via Wnt/β-Catenin Signaling
par: Xiao XH, et autres
Publié: (2019)

Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.
par: Monica Averna, et autres
Publié: (2013)

Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis
par: Luka A. Clarke, et autres
Publié: (2021)

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells
par: Parameet Kumar, et autres
Publié: (2021)

Secuenciación del gen CFTR en un grupo de pacientes chilenos con fibrosis quística
par: LAY-SON R,GUILLERMO, et autres
Publié: (2014)

Identificación de mutaciones en el gen CFTR en pacientes chilenos con fibrosis quística
par: Repetto L,Gabriela, et autres
Publié: (2001)

Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis
par: Thanachai Methatham, et autres
Publié: (2021)

Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway
par: Li Zhang, et autres
Publié: (2021)

A little CFTR goes a long way: CFTR-dependent sweat secretion from G551D and R117H-5T cystic fibrosis subjects taking ivacaftor.
par: Jessica E Char, et autres
Publié: (2014)

Deciphering the mechanoresponsive role of β-catenin in keratoconus epithelium
par: Chatterjee Amit, et autres
Publié: (2020)

The Genetic Analysis of Cystic Fibrosis Patients With Seven Novel Mutations in the CFTR Gene in the Central Anatolian Region of Turkey
par: Murat Erdoğan, et autres
Publié: (2021)

Apoptosis of mesenchymal stem cells is regulated by Rspo1 via the Wnt/β-catenin signaling pathway
par: Xiao-Xia Cheng, et autres
Publié: (2019)

Identification of lead vacancy defects in lead halide perovskites
par: David J. Keeble, et autres
Publié: (2021)

Integrative genomic meta-analysis reveals novel molecular insights into cystic fibrosis and ΔF508-CFTR rescue
par: Rachel A. Hodos, et autres
Publié: (2020)

XV-2c and KM: 19 haplotype analysis in Chilean patients with cystic fibrosis and unknown CFTR gene mutations
par: REPETTO,GABRIELA M, et autres
Publié: (2007)

A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis
par: Hwajung Choi, et autres
Publié: (2017)