Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway

Abstract The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder characterized by the execution of repetitiv...

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Autores principales:	Anca Rădulescu, Joanna Herron, Caitlin Kennedy, Annalisa Scimemi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/12e46d4fea3941eb86aff1f91fd0e89f
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spelling	oai:doaj.org-article:12e46d4fea3941eb86aff1f91fd0e89f2021-12-02T12:32:54ZGlobal and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway10.1038/s41598-017-07527-82045-2322https://doaj.org/article/12e46d4fea3941eb86aff1f91fd0e89f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07527-8https://doaj.org/toc/2045-2322Abstract The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder characterized by the execution of repetitive involuntary movements. The striatum shapes the activity of the CSTC pathway through the coordinated activation of two classes of medium spiny neurons (MSNs) expressing D1 or D2 dopamine receptors. The exact mechanisms by which balanced excitation/inhibition (E/I) of these cells controls the network dynamics of the CSTC pathway remain unclear. Here we use non-linear modeling of neuronal activity and bifurcation theory to investigate how global and local changes in E/I of MSNs regulate the activity of the CSTC pathway. Our findings indicate that a global and proportionate increase in E/I pushes the system to states of generalized hyper-activity throughout the entire CSTC pathway. Certain disproportionate changes in global E/I trigger network oscillations. Local changes in the E/I of MSNs generate specific oscillatory behaviors in MSNs and in the CSTC pathway. These findings indicate that subtle changes in the relative strength of E/I of MSNs can powerfully control the network dynamics of the CSTC pathway in ways that are not easily predicted by its synaptic connections.Anca RădulescuJoanna HerronCaitlin KennedyAnnalisa ScimemiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-21 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anca Rădulescu Joanna Herron Caitlin Kennedy Annalisa Scimemi Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
description	Abstract The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder characterized by the execution of repetitive involuntary movements. The striatum shapes the activity of the CSTC pathway through the coordinated activation of two classes of medium spiny neurons (MSNs) expressing D1 or D2 dopamine receptors. The exact mechanisms by which balanced excitation/inhibition (E/I) of these cells controls the network dynamics of the CSTC pathway remain unclear. Here we use non-linear modeling of neuronal activity and bifurcation theory to investigate how global and local changes in E/I of MSNs regulate the activity of the CSTC pathway. Our findings indicate that a global and proportionate increase in E/I pushes the system to states of generalized hyper-activity throughout the entire CSTC pathway. Certain disproportionate changes in global E/I trigger network oscillations. Local changes in the E/I of MSNs generate specific oscillatory behaviors in MSNs and in the CSTC pathway. These findings indicate that subtle changes in the relative strength of E/I of MSNs can powerfully control the network dynamics of the CSTC pathway in ways that are not easily predicted by its synaptic connections.
format	article
author	Anca Rădulescu Joanna Herron Caitlin Kennedy Annalisa Scimemi
author_facet	Anca Rădulescu Joanna Herron Caitlin Kennedy Annalisa Scimemi
author_sort	Anca Rădulescu
title	Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
title_short	Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
title_full	Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
title_fullStr	Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
title_full_unstemmed	Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
title_sort	global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/12e46d4fea3941eb86aff1f91fd0e89f
work_keys_str_mv	AT ancaradulescu globalandlocalexcitationandinhibitionshapethedynamicsofthecorticostriatalthalamocorticalpathway AT joannaherron globalandlocalexcitationandinhibitionshapethedynamicsofthecorticostriatalthalamocorticalpathway AT caitlinkennedy globalandlocalexcitationandinhibitionshapethedynamicsofthecorticostriatalthalamocorticalpathway AT annalisascimemi globalandlocalexcitationandinhibitionshapethedynamicsofthecorticostriatalthalamocorticalpathway
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Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway

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