Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques

Abstract The role of inflammation in cardiovascular pathophysiology has gained a lot of research interest in recent years. Cardiovascular Magnetic Resonance has been a powerful tool in the non-invasive assessment of inflammation in several conditions. More recently, Ultrasmall superparamagnetic part...

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Autores principales:	Vasiliki Tsampasian, Andrew J. Swift, Hosamadin Assadi, Amrit Chowdhary, Peter Swoboda, Eva Sammut, Amardeep Dastidar, Jordi Broncano Cabrero, Javier Royuela Del Val, Sunil Nair, Robin Nijveldt, Alisdair Ryding, Chris Sawh, Chiara Bucciarelli-Ducci, Eylem Levelt, Vassilios Vassiliou, Pankaj Garg
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cardiovascular magnetic resonance (CMR) Ultrasmall superparamagnetic particles of iron oxide (USPIO) Magnetic resonance spectroscopy (MRS) Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/12ed74b8035543d19c5654abad423459
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spelling	oai:doaj.org-article:12ed74b8035543d19c5654abad4234592021-11-14T12:33:34ZMyocardial inflammation and energetics by cardiac MRI: a review of emerging techniques10.1186/s12880-021-00695-01471-2342https://doaj.org/article/12ed74b8035543d19c5654abad4234592021-11-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00695-0https://doaj.org/toc/1471-2342Abstract The role of inflammation in cardiovascular pathophysiology has gained a lot of research interest in recent years. Cardiovascular Magnetic Resonance has been a powerful tool in the non-invasive assessment of inflammation in several conditions. More recently, Ultrasmall superparamagnetic particles of iron oxide have been successfully used to evaluate macrophage activity and subsequently inflammation on a cellular level. Current evidence from research studies provides encouraging data and confirms that this evolving method can potentially have a huge impact on clinical practice as it can be used in the diagnosis and management of very common conditions such as coronary artery disease, ischaemic and non-ischaemic cardiomyopathy, myocarditis and atherosclerosis. Another important emerging concept is that of myocardial energetics. With the use of phosphorus magnetic resonance spectroscopy, myocardial energetic compromise has been proved to be an important feature in the pathophysiological process of several conditions including diabetic cardiomyopathy, inherited cardiomyopathies, valvular heart disease and cardiac transplant rejection. This unique tool is therefore being utilized to assess metabolic alterations in a wide range of cardiovascular diseases. This review systematically examines these state-of-the-art methods in detail and provides an insight into the mechanisms of action and the clinical implications of their use.Vasiliki TsampasianAndrew J. SwiftHosamadin AssadiAmrit ChowdharyPeter SwobodaEva SammutAmardeep DastidarJordi Broncano CabreroJavier Royuela Del ValSunil NairRobin NijveldtAlisdair RydingChris SawhChiara Bucciarelli-DucciEylem LeveltVassilios VassiliouPankaj GargBMCarticleCardiovascular magnetic resonance (CMR)Ultrasmall superparamagnetic particles of iron oxide (USPIO)Magnetic resonance spectroscopy (MRS)Medical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiovascular magnetic resonance (CMR) Ultrasmall superparamagnetic particles of iron oxide (USPIO) Magnetic resonance spectroscopy (MRS) Medical technology R855-855.5
spellingShingle	Cardiovascular magnetic resonance (CMR) Ultrasmall superparamagnetic particles of iron oxide (USPIO) Magnetic resonance spectroscopy (MRS) Medical technology R855-855.5 Vasiliki Tsampasian Andrew J. Swift Hosamadin Assadi Amrit Chowdhary Peter Swoboda Eva Sammut Amardeep Dastidar Jordi Broncano Cabrero Javier Royuela Del Val Sunil Nair Robin Nijveldt Alisdair Ryding Chris Sawh Chiara Bucciarelli-Ducci Eylem Levelt Vassilios Vassiliou Pankaj Garg Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
description	Abstract The role of inflammation in cardiovascular pathophysiology has gained a lot of research interest in recent years. Cardiovascular Magnetic Resonance has been a powerful tool in the non-invasive assessment of inflammation in several conditions. More recently, Ultrasmall superparamagnetic particles of iron oxide have been successfully used to evaluate macrophage activity and subsequently inflammation on a cellular level. Current evidence from research studies provides encouraging data and confirms that this evolving method can potentially have a huge impact on clinical practice as it can be used in the diagnosis and management of very common conditions such as coronary artery disease, ischaemic and non-ischaemic cardiomyopathy, myocarditis and atherosclerosis. Another important emerging concept is that of myocardial energetics. With the use of phosphorus magnetic resonance spectroscopy, myocardial energetic compromise has been proved to be an important feature in the pathophysiological process of several conditions including diabetic cardiomyopathy, inherited cardiomyopathies, valvular heart disease and cardiac transplant rejection. This unique tool is therefore being utilized to assess metabolic alterations in a wide range of cardiovascular diseases. This review systematically examines these state-of-the-art methods in detail and provides an insight into the mechanisms of action and the clinical implications of their use.
format	article
author	Vasiliki Tsampasian Andrew J. Swift Hosamadin Assadi Amrit Chowdhary Peter Swoboda Eva Sammut Amardeep Dastidar Jordi Broncano Cabrero Javier Royuela Del Val Sunil Nair Robin Nijveldt Alisdair Ryding Chris Sawh Chiara Bucciarelli-Ducci Eylem Levelt Vassilios Vassiliou Pankaj Garg
author_facet	Vasiliki Tsampasian Andrew J. Swift Hosamadin Assadi Amrit Chowdhary Peter Swoboda Eva Sammut Amardeep Dastidar Jordi Broncano Cabrero Javier Royuela Del Val Sunil Nair Robin Nijveldt Alisdair Ryding Chris Sawh Chiara Bucciarelli-Ducci Eylem Levelt Vassilios Vassiliou Pankaj Garg
author_sort	Vasiliki Tsampasian
title	Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
title_short	Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
title_full	Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
title_fullStr	Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
title_full_unstemmed	Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
title_sort	myocardial inflammation and energetics by cardiac mri: a review of emerging techniques
publisher	BMC
publishDate	2021
url	https://doaj.org/article/12ed74b8035543d19c5654abad423459
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Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques

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