Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review

Abstract Background We aimed to investigate the clinical characteristics and islet β-cell function in patients with Klinefelter syndrome (KS) and hyperglycemia. Methods This is a retrospective study. In total, 22 patients diagnosed with KS were identified from the electronic medical record system, i...

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Autores principales:	Shixuan Liu, Tao Yuan, Shuoning Song, Shi Chen, Linjie Wang, Yong Fu, Yingyue Dong, Yan Tang, Weigang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Klinefelter syndrome Diabetes mellitus Hyperglycemia Insulin resistance Hypoglycemic therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/12eeb56e30ee45bcb703823937eb5f40
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spelling	oai:doaj.org-article:12eeb56e30ee45bcb703823937eb5f402021-12-05T12:03:17ZGlucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review10.1186/s12902-021-00893-51472-6823https://doaj.org/article/12eeb56e30ee45bcb703823937eb5f402021-12-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00893-5https://doaj.org/toc/1472-6823Abstract Background We aimed to investigate the clinical characteristics and islet β-cell function in patients with Klinefelter syndrome (KS) and hyperglycemia. Methods This is a retrospective study. In total, 22 patients diagnosed with KS were identified from the electronic medical record system, including 9 patients with hyperglycemia (total patients with hyperglycemia, THG-KS group) and 5 hyperglycemic KS patients with oral glucose tolerance test (OGTT) results (HG-KS group). An additional 5 subjects with hyperglycemia and 5 normal glucose tolerance (NGT) subjects matched based on body mass index were included as the HG group and NGT group, respectively. Data from clinical and laboratory examinations were collected. We further performed a literature review of KS and hyperglycemia. Results We found that KS patients developed abnormal glucose metabolism earlier in life than those without KS, and the median age was 17 years, ranging from 10 years to 19 years. Six of 17 (35.3%) patients were diagnosed with diabetes mellitus and 3 of 17 (17.6%) patients were diagnosed with prediabetes. Among 10 patients with both fasting blood glucose and insulin results recorded, there were 8 out of 17 (47.1%) KS patients had insulin resistance. The prevalence of hypertension and dyslipidemia was higher in patients with hyperglycemia and KS than in patients with NGT KS. Compared with the HG group, insulin sensitivity levels were lower in HG-KS group, whereas homeostasis model assessment of β-cell function levels (p = 0.047) were significantly, indicating higher insulin secretion levels in the HG-KS group. Conclusions KS patients develop hyperglycemia earlier in life than those without KS and show lower insulin sensitivity and higher insulin secretion. These patients also have a higher prevalence of other metabolic diseases and may have different frequencies of developing KS-related symptoms.Shixuan LiuTao YuanShuoning SongShi ChenLinjie WangYong FuYingyue DongYan TangWeigang ZhaoBMCarticleKlinefelter syndromeDiabetes mellitusHyperglycemiaInsulin resistanceHypoglycemic therapyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Klinefelter syndrome Diabetes mellitus Hyperglycemia Insulin resistance Hypoglycemic therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Klinefelter syndrome Diabetes mellitus Hyperglycemia Insulin resistance Hypoglycemic therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665 Shixuan Liu Tao Yuan Shuoning Song Shi Chen Linjie Wang Yong Fu Yingyue Dong Yan Tang Weigang Zhao Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
description	Abstract Background We aimed to investigate the clinical characteristics and islet β-cell function in patients with Klinefelter syndrome (KS) and hyperglycemia. Methods This is a retrospective study. In total, 22 patients diagnosed with KS were identified from the electronic medical record system, including 9 patients with hyperglycemia (total patients with hyperglycemia, THG-KS group) and 5 hyperglycemic KS patients with oral glucose tolerance test (OGTT) results (HG-KS group). An additional 5 subjects with hyperglycemia and 5 normal glucose tolerance (NGT) subjects matched based on body mass index were included as the HG group and NGT group, respectively. Data from clinical and laboratory examinations were collected. We further performed a literature review of KS and hyperglycemia. Results We found that KS patients developed abnormal glucose metabolism earlier in life than those without KS, and the median age was 17 years, ranging from 10 years to 19 years. Six of 17 (35.3%) patients were diagnosed with diabetes mellitus and 3 of 17 (17.6%) patients were diagnosed with prediabetes. Among 10 patients with both fasting blood glucose and insulin results recorded, there were 8 out of 17 (47.1%) KS patients had insulin resistance. The prevalence of hypertension and dyslipidemia was higher in patients with hyperglycemia and KS than in patients with NGT KS. Compared with the HG group, insulin sensitivity levels were lower in HG-KS group, whereas homeostasis model assessment of β-cell function levels (p = 0.047) were significantly, indicating higher insulin secretion levels in the HG-KS group. Conclusions KS patients develop hyperglycemia earlier in life than those without KS and show lower insulin sensitivity and higher insulin secretion. These patients also have a higher prevalence of other metabolic diseases and may have different frequencies of developing KS-related symptoms.
format	article
author	Shixuan Liu Tao Yuan Shuoning Song Shi Chen Linjie Wang Yong Fu Yingyue Dong Yan Tang Weigang Zhao
author_facet	Shixuan Liu Tao Yuan Shuoning Song Shi Chen Linjie Wang Yong Fu Yingyue Dong Yan Tang Weigang Zhao
author_sort	Shixuan Liu
title	Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
title_short	Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
title_full	Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
title_fullStr	Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
title_full_unstemmed	Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
title_sort	glucose metabolic disorder in klinefelter syndrome: a retrospective analysis in a single chinese hospital and literature review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/12eeb56e30ee45bcb703823937eb5f40
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Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review

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