Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects

Bilberry (Vaccinium myrtillus L.) is a medicinal fruit known for its high content of anthocyanins, flavonoids, vitamins, ascorbic acid, carotenoids, tocopherols and phenolic acid. Bilberry has long been used in oriental medicine for the prevention and treatment of various diseases, such as visual ac...

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Autores principales:	Al Borhan Bayazid, Eun Mi Chun, Mohammad Al Mijan, Seo Hyun Park, Sung-Kwon Moon, Beong Ou Lim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	bilberry anthocyanins antioxidant inflammations raw 264.7 cells lps Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/12ef84e3e5b94d45850c6ae260313a9e
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spelling	oai:doaj.org-article:12ef84e3e5b94d45850c6ae260313a9e2021-11-04T15:00:41ZAnthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects0954-01051465-344310.1080/09540105.2021.1986471https://doaj.org/article/12ef84e3e5b94d45850c6ae260313a9e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2021.1986471https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Bilberry (Vaccinium myrtillus L.) is a medicinal fruit known for its high content of anthocyanins, flavonoids, vitamins, ascorbic acid, carotenoids, tocopherols and phenolic acid. Bilberry has long been used in oriental medicine for the prevention and treatment of various diseases, such as visual acuity, hyperglycemia, dyslipidemia, diabetes, cancer, obesity, inflammatory and cardiovascular diseases. In this study, we investigated using the antioxidant and anti-inflammatory of 70% ethanol extracts of bilberry in vitro. Antioxidant activities were measured with total phenolic, flavonoid and ascorbic acid contents. The bilberry extract (BE) showed significant free radical scavenging activities and inhibited oxidation of linoleic acid in a dose-dependent manner. BE also suppressed nitric oxide (NO) generation and reversed pro-inflammatory cytokines such as iNOS, COX-2, TNF-α and IL-6 in LPS-induced RAW 264.7 cells. From these results, we suggest that BE is a natural powerful antioxidant, and the anti-inflammatory agent being a rich source of anthocyanins.Al Borhan BayazidEun Mi ChunMohammad Al MijanSeo Hyun ParkSung-Kwon MoonBeong Ou LimTaylor & Francis Grouparticlebilberryanthocyaninsantioxidantinflammationsraw 264.7 cellslpsAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 32, Iss 1, Pp 713-726 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bilberry anthocyanins antioxidant inflammations raw 264.7 cells lps Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	bilberry anthocyanins antioxidant inflammations raw 264.7 cells lps Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Al Borhan Bayazid Eun Mi Chun Mohammad Al Mijan Seo Hyun Park Sung-Kwon Moon Beong Ou Lim Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects
description	Bilberry (Vaccinium myrtillus L.) is a medicinal fruit known for its high content of anthocyanins, flavonoids, vitamins, ascorbic acid, carotenoids, tocopherols and phenolic acid. Bilberry has long been used in oriental medicine for the prevention and treatment of various diseases, such as visual acuity, hyperglycemia, dyslipidemia, diabetes, cancer, obesity, inflammatory and cardiovascular diseases. In this study, we investigated using the antioxidant and anti-inflammatory of 70% ethanol extracts of bilberry in vitro. Antioxidant activities were measured with total phenolic, flavonoid and ascorbic acid contents. The bilberry extract (BE) showed significant free radical scavenging activities and inhibited oxidation of linoleic acid in a dose-dependent manner. BE also suppressed nitric oxide (NO) generation and reversed pro-inflammatory cytokines such as iNOS, COX-2, TNF-α and IL-6 in LPS-induced RAW 264.7 cells. From these results, we suggest that BE is a natural powerful antioxidant, and the anti-inflammatory agent being a rich source of anthocyanins.
format	article
author	Al Borhan Bayazid Eun Mi Chun Mohammad Al Mijan Seo Hyun Park Sung-Kwon Moon Beong Ou Lim
author_facet	Al Borhan Bayazid Eun Mi Chun Mohammad Al Mijan Seo Hyun Park Sung-Kwon Moon Beong Ou Lim
author_sort	Al Borhan Bayazid
title	Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects
title_short	Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects
title_full	Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects
title_fullStr	Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects
title_full_unstemmed	Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects
title_sort	anthocyanins profiling of bilberry (vaccinium myrtillus l.) extract that elucidates antioxidant and anti-inflammatory effects
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/12ef84e3e5b94d45850c6ae260313a9e
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Anthocyanins profiling of bilberry (Vaccinium myrtillus L.) extract that elucidates antioxidant and anti-inflammatory effects

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