Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility

ABSTRACT Various bacterial pathogens display an intracellular lifestyle and spread from cell to cell through actin-based motility (ABM). ABM requires actin polymerization at the bacterial pole and is mediated by the expression of bacterial factors that hijack the host cell actin nucleation machinery...

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Autores principales:	Volkan K. Köseoğlu, Hervé Agaisse
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	ActA actin-based motility IcsA Listeria Shigella adhesion Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/12f053c0e21b4cd4bc5da2297b72b2cf
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spelling	oai:doaj.org-article:12f053c0e21b4cd4bc5da2297b72b2cf2021-11-15T16:22:11ZEvolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility10.1128/mBio.01520-192150-7511https://doaj.org/article/12f053c0e21b4cd4bc5da2297b72b2cf2019-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01520-19https://doaj.org/toc/2150-7511ABSTRACT Various bacterial pathogens display an intracellular lifestyle and spread from cell to cell through actin-based motility (ABM). ABM requires actin polymerization at the bacterial pole and is mediated by the expression of bacterial factors that hijack the host cell actin nucleation machinery or exhibit intrinsic actin nucleation properties. It is increasingly recognized that bacterial ABM factors, in addition to having a crucial task during the intracellular phase of infection, display “moonlighting” adhesin functions, such as bacterial aggregation, biofilm formation, and host cell adhesion/invasion. Here, we review our current knowledge of ABM factors and their additional functions, and we propose that intracellular ABM functions have evolved from ancestral, extracellular adhesin functions.Volkan K. KöseoğluHervé AgaisseAmerican Society for MicrobiologyarticleActAactin-based motilityIcsAListeriaShigellaadhesionMicrobiologyQR1-502ENmBio, Vol 10, Iss 4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ActA actin-based motility IcsA Listeria Shigella adhesion Microbiology QR1-502
spellingShingle	ActA actin-based motility IcsA Listeria Shigella adhesion Microbiology QR1-502 Volkan K. Köseoğlu Hervé Agaisse Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility
description	ABSTRACT Various bacterial pathogens display an intracellular lifestyle and spread from cell to cell through actin-based motility (ABM). ABM requires actin polymerization at the bacterial pole and is mediated by the expression of bacterial factors that hijack the host cell actin nucleation machinery or exhibit intrinsic actin nucleation properties. It is increasingly recognized that bacterial ABM factors, in addition to having a crucial task during the intracellular phase of infection, display “moonlighting” adhesin functions, such as bacterial aggregation, biofilm formation, and host cell adhesion/invasion. Here, we review our current knowledge of ABM factors and their additional functions, and we propose that intracellular ABM functions have evolved from ancestral, extracellular adhesin functions.
format	article
author	Volkan K. Köseoğlu Hervé Agaisse
author_facet	Volkan K. Köseoğlu Hervé Agaisse
author_sort	Volkan K. Köseoğlu
title	Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility
title_short	Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility
title_full	Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility
title_fullStr	Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility
title_full_unstemmed	Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility
title_sort	evolutionary perspectives on the moonlighting functions of bacterial factors that support actin-based motility
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/12f053c0e21b4cd4bc5da2297b72b2cf
work_keys_str_mv	AT volkankkoseoglu evolutionaryperspectivesonthemoonlightingfunctionsofbacterialfactorsthatsupportactinbasedmotility AT herveagaisse evolutionaryperspectivesonthemoonlightingfunctionsofbacterialfactorsthatsupportactinbasedmotility
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Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility

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