KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.

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Autores principales:	Lin Song, Shi Tang, Xiaolei Han, Ziying Jiang, Lingling Dong, Cuicui Liu, Xiaoyan Liang, Jixin Dong, Chengxuan Qiu, Yongxiang Wang, Yifeng Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12fccc7fe05b497ebe3e4f337cbea047
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spelling	oai:doaj.org-article:12fccc7fe05b497ebe3e4f337cbea0472021-12-02T17:33:22ZKIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a10.1038/s41467-019-09720-x2041-1723https://doaj.org/article/12fccc7fe05b497ebe3e4f337cbea0472019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09720-xhttps://doaj.org/toc/2041-1723Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.Lin SongShi TangXiaolei HanZiying JiangLingling DongCuicui LiuXiaoyan LiangJixin DongChengxuan QiuYongxiang WangYifeng DuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin Song Shi Tang Xiaolei Han Ziying Jiang Lingling Dong Cuicui Liu Xiaoyan Liang Jixin Dong Chengxuan Qiu Yongxiang Wang Yifeng Du KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
description	Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.
format	article
author	Lin Song Shi Tang Xiaolei Han Ziying Jiang Lingling Dong Cuicui Liu Xiaoyan Liang Jixin Dong Chengxuan Qiu Yongxiang Wang Yifeng Du
author_facet	Lin Song Shi Tang Xiaolei Han Ziying Jiang Lingling Dong Cuicui Liu Xiaoyan Liang Jixin Dong Chengxuan Qiu Yongxiang Wang Yifeng Du
author_sort	Lin Song
title	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
title_short	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
title_full	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
title_fullStr	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
title_full_unstemmed	KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
title_sort	kibra controls exosome secretion via inhibiting the proteasomal degradation of rab27a
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/12fccc7fe05b497ebe3e4f337cbea047
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KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

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