KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.

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Detalles Bibliográficos
Autores principales: Lin Song, Shi Tang, Xiaolei Han, Ziying Jiang, Lingling Dong, Cuicui Liu, Xiaoyan Liang, Jixin Dong, Chengxuan Qiu, Yongxiang Wang, Yifeng Du
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/12fccc7fe05b497ebe3e4f337cbea047
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