Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice

Cuillerier et al. investigate compensatory mechanisms underlying survival of mice with a liver-specific knockout of the mitochondrial mRNA-binding protein Lrpprc. They propose various mechanisms operating along the OXPHOS assembly line, including mitochondrial biogenesis, mitochondrial ribosome upre...

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Autores principales:	Alexanne Cuillerier, Matthieu Ruiz, Caroline Daneault, Anik Forest, Jenna Rossi, Goutham Vasam, George Cairns, Virgilio Cadete, The LSFC Consortium, Christine Des Rosiers, Yan Burelle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/12fd84a866144bb181cee682a2036138
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spelling	oai:doaj.org-article:12fd84a866144bb181cee682a20361382021-12-02T18:51:45ZAdaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice10.1038/s42003-021-02492-52399-3642https://doaj.org/article/12fd84a866144bb181cee682a20361382021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02492-5https://doaj.org/toc/2399-3642Cuillerier et al. investigate compensatory mechanisms underlying survival of mice with a liver-specific knockout of the mitochondrial mRNA-binding protein Lrpprc. They propose various mechanisms operating along the OXPHOS assembly line, including mitochondrial biogenesis, mitochondrial ribosome upregulation and preferential supercomplex assembly, that could compensate lack of LRPPRC and allow survival of these mice.Alexanne CuillerierMatthieu RuizCaroline DaneaultAnik ForestJenna RossiGoutham VasamGeorge CairnsVirgilio CadeteThe LSFC ConsortiumChristine Des RosiersYan BurelleNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alexanne Cuillerier Matthieu Ruiz Caroline Daneault Anik Forest Jenna Rossi Goutham Vasam George Cairns Virgilio Cadete The LSFC Consortium Christine Des Rosiers Yan Burelle Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
description	Cuillerier et al. investigate compensatory mechanisms underlying survival of mice with a liver-specific knockout of the mitochondrial mRNA-binding protein Lrpprc. They propose various mechanisms operating along the OXPHOS assembly line, including mitochondrial biogenesis, mitochondrial ribosome upregulation and preferential supercomplex assembly, that could compensate lack of LRPPRC and allow survival of these mice.
format	article
author	Alexanne Cuillerier Matthieu Ruiz Caroline Daneault Anik Forest Jenna Rossi Goutham Vasam George Cairns Virgilio Cadete The LSFC Consortium Christine Des Rosiers Yan Burelle
author_facet	Alexanne Cuillerier Matthieu Ruiz Caroline Daneault Anik Forest Jenna Rossi Goutham Vasam George Cairns Virgilio Cadete The LSFC Consortium Christine Des Rosiers Yan Burelle
author_sort	Alexanne Cuillerier
title	Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
title_short	Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
title_full	Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
title_fullStr	Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
title_full_unstemmed	Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
title_sort	adaptive optimization of the oxphos assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12fd84a866144bb181cee682a2036138
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Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice

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