The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis

NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recr...

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Autores principales:	Federica Fusella, Laura Seclì, Elena Busso, Anna Krepelova, Enrico Moiso, Stefania Rocca, Laura Conti, Laura Annaratone, Cristina Rubinetto, Maurizia Mello-Grand, Vijay Singh, Giovanna Chiorino, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Alessandro Morotti, Salvatore Oliviero, Isabella Castellano, Federica Cavallo, Paolo Provero, Guido Tarone, Mara Brancaccio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c15661
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spelling	oai:doaj.org-article:12fe3e6cb2cb4e56ad2f805e25c156612021-12-02T15:39:02ZThe IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis10.1038/s41467-017-01829-12041-1723https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c156612017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01829-1https://doaj.org/toc/2041-1723NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recruitment.Federica FusellaLaura SeclìElena BussoAnna KrepelovaEnrico MoisoStefania RoccaLaura ContiLaura AnnaratoneCristina RubinettoMaurizia Mello-GrandVijay SinghGiovanna ChiorinoLorenzo SilengoFiorella AltrudaEmilia TurcoAlessandro MorottiSalvatore OlivieroIsabella CastellanoFederica CavalloPaolo ProveroGuido TaroneMara BrancaccioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Federica Fusella Laura Seclì Elena Busso Anna Krepelova Enrico Moiso Stefania Rocca Laura Conti Laura Annaratone Cristina Rubinetto Maurizia Mello-Grand Vijay Singh Giovanna Chiorino Lorenzo Silengo Fiorella Altruda Emilia Turco Alessandro Morotti Salvatore Oliviero Isabella Castellano Federica Cavallo Paolo Provero Guido Tarone Mara Brancaccio The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
description	NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB activation to promote metastasis and neutrophil recruitment.
format	article
author	Federica Fusella Laura Seclì Elena Busso Anna Krepelova Enrico Moiso Stefania Rocca Laura Conti Laura Annaratone Cristina Rubinetto Maurizia Mello-Grand Vijay Singh Giovanna Chiorino Lorenzo Silengo Fiorella Altruda Emilia Turco Alessandro Morotti Salvatore Oliviero Isabella Castellano Federica Cavallo Paolo Provero Guido Tarone Mara Brancaccio
author_facet	Federica Fusella Laura Seclì Elena Busso Anna Krepelova Enrico Moiso Stefania Rocca Laura Conti Laura Annaratone Cristina Rubinetto Maurizia Mello-Grand Vijay Singh Giovanna Chiorino Lorenzo Silengo Fiorella Altruda Emilia Turco Alessandro Morotti Salvatore Oliviero Isabella Castellano Federica Cavallo Paolo Provero Guido Tarone Mara Brancaccio
author_sort	Federica Fusella
title	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_short	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_full	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_fullStr	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_full_unstemmed	The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
title_sort	ikk/nf-κb signaling pathway requires morgana to drive breast cancer metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c15661
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The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis

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