GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therap...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/130018a3112a40a29ff505012c3352a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:130018a3112a40a29ff505012c3352a4
record_format	dspace
spelling	oai:doaj.org-article:130018a3112a40a29ff505012c3352a42021-12-02T17:08:26ZGLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer10.1038/s41467-020-18020-82041-1723https://doaj.org/article/130018a3112a40a29ff505012c3352a42020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18020-8https://doaj.org/toc/2041-1723Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therapy.Qin WuWail ba-alawiGenevieve DebloisJennifer CruickshankShili DuanEvelyne Lima-FernandesJillian HaightSeyed Ali Madani TonekaboniAnne-Marie FortierHellen KuasneTrevor D. McKeeHassan MahmoudMichelle KushidaSarina CameronNergiz Dogan-ArtunWenJun ChenYan NieLan Xin ZhangRavi N. VellankiStanley ZhouPanagiotis PrinosBradly G. WoutersPeter B. DirksSusan J. DoneMorag ParkDavid W. CesconBenjamin Haibe-KainsMathieu LupienCheryl H. ArrowsmithNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qin Wu Wail ba-alawi Genevieve Deblois Jennifer Cruickshank Shili Duan Evelyne Lima-Fernandes Jillian Haight Seyed Ali Madani Tonekaboni Anne-Marie Fortier Hellen Kuasne Trevor D. McKee Hassan Mahmoud Michelle Kushida Sarina Cameron Nergiz Dogan-Artun WenJun Chen Yan Nie Lan Xin Zhang Ravi N. Vellanki Stanley Zhou Panagiotis Prinos Bradly G. Wouters Peter B. Dirks Susan J. Done Morag Park David W. Cescon Benjamin Haibe-Kains Mathieu Lupien Cheryl H. Arrowsmith GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
description	Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therapy.
format	article
author	Qin Wu Wail ba-alawi Genevieve Deblois Jennifer Cruickshank Shili Duan Evelyne Lima-Fernandes Jillian Haight Seyed Ali Madani Tonekaboni Anne-Marie Fortier Hellen Kuasne Trevor D. McKee Hassan Mahmoud Michelle Kushida Sarina Cameron Nergiz Dogan-Artun WenJun Chen Yan Nie Lan Xin Zhang Ravi N. Vellanki Stanley Zhou Panagiotis Prinos Bradly G. Wouters Peter B. Dirks Susan J. Done Morag Park David W. Cescon Benjamin Haibe-Kains Mathieu Lupien Cheryl H. Arrowsmith
author_facet	Qin Wu Wail ba-alawi Genevieve Deblois Jennifer Cruickshank Shili Duan Evelyne Lima-Fernandes Jillian Haight Seyed Ali Madani Tonekaboni Anne-Marie Fortier Hellen Kuasne Trevor D. McKee Hassan Mahmoud Michelle Kushida Sarina Cameron Nergiz Dogan-Artun WenJun Chen Yan Nie Lan Xin Zhang Ravi N. Vellanki Stanley Zhou Panagiotis Prinos Bradly G. Wouters Peter B. Dirks Susan J. Done Morag Park David W. Cescon Benjamin Haibe-Kains Mathieu Lupien Cheryl H. Arrowsmith
author_sort	Qin Wu
title	GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
title_short	GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
title_full	GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
title_fullStr	GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
title_full_unstemmed	GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
title_sort	glut1 inhibition blocks growth of rb1-positive triple negative breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/130018a3112a40a29ff505012c3352a4
work_keys_str_mv	AT qinwu glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT wailbaalawi glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT genevievedeblois glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT jennifercruickshank glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT shiliduan glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT evelynelimafernandes glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT jillianhaight glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT seyedalimadanitonekaboni glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT annemariefortier glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT hellenkuasne glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT trevordmckee glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT hassanmahmoud glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT michellekushida glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT sarinacameron glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT nergizdoganartun glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT wenjunchen glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT yannie glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT lanxinzhang glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT ravinvellanki glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT stanleyzhou glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT panagiotisprinos glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT bradlygwouters glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT peterbdirks glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT susanjdone glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT moragpark glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT davidwcescon glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT benjaminhaibekains glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT mathieulupien glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer AT cherylharrowsmith glut1inhibitionblocksgrowthofrb1positivetriplenegativebreastcancer
_version_	1718381539652272128

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Ejemplares similares