Association of Admission Blood Glucose Level with All-Cause Mortality According to Age in Patients with Community Acquired Pneumonia
Yejing Shen,1,2 Xiaowen Xu,2 Siming Meng,2 Meng Qin,2 Hailing Li,2 Dejie Chu,1 Cuixia Zheng2 1Department of Respiratory Medicine, Shanghai Eighth People’s Hospital, Shanghai, 200235, People’s Republic of China; 2Department of Respiratory Medicine, Yangpu Hospital Affiliated to Tongji University, Sha...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/1302ecf7d26d43a684ccfb559a818975 |
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| Sumario: | Yejing Shen,1,2 Xiaowen Xu,2 Siming Meng,2 Meng Qin,2 Hailing Li,2 Dejie Chu,1 Cuixia Zheng2 1Department of Respiratory Medicine, Shanghai Eighth People’s Hospital, Shanghai, 200235, People’s Republic of China; 2Department of Respiratory Medicine, Yangpu Hospital Affiliated to Tongji University, Shanghai, 200090, People’s Republic of ChinaCorrespondence: Dejie ChuDepartment of Respiratory Medicine, Shanghai Eighth People’s Hospital, 8 Caobao Road, Shanghai, 200235, People’s Republic of ChinaEmail chudejie@yandex.comCuixia ZhengDepartment of Respiratory Medicine, Yangpu Hospital Affiliated to Tongji University, 450 Tengyue Road, Shanghai, 200090, People’s Republic of ChinaEmail zhengcuixiash@163.comObjective: To assess the impact of blood glucose levels on the prognosis of patients with community-acquired pneumonia (CAP) who were elderly or middle-aged.Methods: From January 1, 2018, to December 31, 2020, patients with CAP (≥ 45 years) were retrospectively enrolled in this observational study. They were stratified by age (45– 64 or ≥ 65 years) and blood glucose level (≥ 11.1 or < 11.1 mmol/l). The effect of admission blood glucose on 28-day mortality was assessed with the Cox proportional hazards model, adjusted for demographic factors and comorbidity.Results: Among 1656 patients with CAP, increased blood glucose (HR=2.08, 95% CI: 1.38– 3.49; P< 0.01) and advanced age (HR=2.76, 95% CI: 1.65– 3.77; P< 0.01) were significantly associated with a higher risk of 28-day mortality, after controlling for potential confounding factors. The strength of the association of blood glucose level with 28-day mortality decreased with age (P=0.01 for the interaction) as the adjusted HRs for death were 4.48 (95% CI: 1.40– 13.65; P< 0.01) for middle-age patients 45– 64 years and 1.52 (95% CI: 1.09– 2.17; P=0.05) for elderly patients ≥ 65 years.Conclusion: The association of blood glucose level upon admission for CAP with all-cause mortality was stronger at younger ages.Keywords: age, community-acquired pneumonia, hyperglycemia, mortality, prognosis |
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