Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?
<h4>Background</h4>Repetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.<h4>Methods</h4>166 consecuti...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2010
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/130348a32ee14f139f913709d69e269f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:130348a32ee14f139f913709d69e269f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:130348a32ee14f139f913709d69e269f2021-11-18T06:34:47ZRepetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?1932-620310.1371/journal.pone.0012959https://doaj.org/article/130348a32ee14f139f913709d69e269f2010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20885982/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Repetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.<h4>Methods</h4>166 consecutive patients with GTS aged 15-68 years were recruited and submitted to extensive neurological, psychiatric and psychological evaluations. RB were evaluated by the YBOCS symptom checklist and Mini International Neuropsychiatric Interview (M.I.N.I), and classified on the basis of a semi-directive psychiatric interview as compulsions or tics.<h4>Results</h4>RB were present in 64.4% of patients with GTS (107/166) and categorised into 3 major groups: a 'tic-like' group (24.3%-40/166) characterised by RB such as touching, counting, 'just right' and symmetry searching; an 'OCD-like' group (20.5%-34/166) with washing and checking rituals; and a 'mixed' group (13.2%-22/166) with both 'tics-like' and 'OCD-like' types of RB present in the same patient. In 6.3% of patients, RB could not be classified into any of these groups and were thus considered 'undetermined'.<h4>Conclusions</h4>The results confirm the phenomenological heterogeneity of RB in GTS patients and allows to distinguish two types: tic-like behaviours which are very likely an integral part of GTS; and OCD-like behaviours, which can be considered as a comorbid condition of GTS and were correlated with higher score of complex tics, neuroleptic and SSRIs treatment frequency and less successful socio-professional adaptation. We suggest that a meticulous semiological analysis of RB in GTS patients will help to tailor treatment and allow to better classify patients for future pathophysiologic studies.<h4>Trial registration</h4>ClinicalTrials.gov NCT00169351.Yulia WorbeLuc MalletJean-Louis GolmardCécile BéharFranck DurifIsabelle JalenquesPhilippe DamierPascal DerkinderenPierre PollakMathieu AnheimEmannuel BroussolleJing XieValérie MesnageKarl MondonFrançois VialletPierre JedynakMouna Ben DjebaraMichael SchüpbachAntoine PelissoloMarie VidailhetYves AgidJean-Luc HouetoAndreas HartmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9, p e12959 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yulia Worbe Luc Mallet Jean-Louis Golmard Cécile Béhar Franck Durif Isabelle Jalenques Philippe Damier Pascal Derkinderen Pierre Pollak Mathieu Anheim Emannuel Broussolle Jing Xie Valérie Mesnage Karl Mondon François Viallet Pierre Jedynak Mouna Ben Djebara Michael Schüpbach Antoine Pelissolo Marie Vidailhet Yves Agid Jean-Luc Houeto Andreas Hartmann Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? |
| description |
<h4>Background</h4>Repetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.<h4>Methods</h4>166 consecutive patients with GTS aged 15-68 years were recruited and submitted to extensive neurological, psychiatric and psychological evaluations. RB were evaluated by the YBOCS symptom checklist and Mini International Neuropsychiatric Interview (M.I.N.I), and classified on the basis of a semi-directive psychiatric interview as compulsions or tics.<h4>Results</h4>RB were present in 64.4% of patients with GTS (107/166) and categorised into 3 major groups: a 'tic-like' group (24.3%-40/166) characterised by RB such as touching, counting, 'just right' and symmetry searching; an 'OCD-like' group (20.5%-34/166) with washing and checking rituals; and a 'mixed' group (13.2%-22/166) with both 'tics-like' and 'OCD-like' types of RB present in the same patient. In 6.3% of patients, RB could not be classified into any of these groups and were thus considered 'undetermined'.<h4>Conclusions</h4>The results confirm the phenomenological heterogeneity of RB in GTS patients and allows to distinguish two types: tic-like behaviours which are very likely an integral part of GTS; and OCD-like behaviours, which can be considered as a comorbid condition of GTS and were correlated with higher score of complex tics, neuroleptic and SSRIs treatment frequency and less successful socio-professional adaptation. We suggest that a meticulous semiological analysis of RB in GTS patients will help to tailor treatment and allow to better classify patients for future pathophysiologic studies.<h4>Trial registration</h4>ClinicalTrials.gov NCT00169351. |
| format |
article |
| author |
Yulia Worbe Luc Mallet Jean-Louis Golmard Cécile Béhar Franck Durif Isabelle Jalenques Philippe Damier Pascal Derkinderen Pierre Pollak Mathieu Anheim Emannuel Broussolle Jing Xie Valérie Mesnage Karl Mondon François Viallet Pierre Jedynak Mouna Ben Djebara Michael Schüpbach Antoine Pelissolo Marie Vidailhet Yves Agid Jean-Luc Houeto Andreas Hartmann |
| author_facet |
Yulia Worbe Luc Mallet Jean-Louis Golmard Cécile Béhar Franck Durif Isabelle Jalenques Philippe Damier Pascal Derkinderen Pierre Pollak Mathieu Anheim Emannuel Broussolle Jing Xie Valérie Mesnage Karl Mondon François Viallet Pierre Jedynak Mouna Ben Djebara Michael Schüpbach Antoine Pelissolo Marie Vidailhet Yves Agid Jean-Luc Houeto Andreas Hartmann |
| author_sort |
Yulia Worbe |
| title |
Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? |
| title_short |
Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? |
| title_full |
Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? |
| title_fullStr |
Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? |
| title_full_unstemmed |
Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? |
| title_sort |
repetitive behaviours in patients with gilles de la tourette syndrome: tics, compulsions, or both? |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/130348a32ee14f139f913709d69e269f |
| work_keys_str_mv |
AT yuliaworbe repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT lucmallet repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT jeanlouisgolmard repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT cecilebehar repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT franckdurif repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT isabellejalenques repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT philippedamier repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT pascalderkinderen repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT pierrepollak repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT mathieuanheim repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT emannuelbroussolle repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT jingxie repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT valeriemesnage repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT karlmondon repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT francoisviallet repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT pierrejedynak repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT mounabendjebara repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT michaelschupbach repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT antoinepelissolo repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT marievidailhet repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT yvesagid repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT jeanluchoueto repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth AT andreashartmann repetitivebehavioursinpatientswithgillesdelatourettesyndrometicscompulsionsorboth |
| _version_ |
1718424460773556224 |