Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.

Any change in the invariant aspects of the auditory environment is of potential importance. The human brain preattentively or automatically detects such changes. The mismatch negativity (MMN) of event-related potentials (ERPs) reflects this initial stage of auditory change detection. The origin of M...

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Autores principales:	Timo Ruusuvirta, Arto Lipponen, Eeva Pellinen, Markku Penttonen, Piia Astikainen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/130a59e5e0d541508c8589e45f8b12ce
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spelling	oai:doaj.org-article:130a59e5e0d541508c8589e45f8b12ce2021-11-18T08:00:30ZAuditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.1932-620310.1371/journal.pone.0054624https://doaj.org/article/130a59e5e0d541508c8589e45f8b12ce2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23355884/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Any change in the invariant aspects of the auditory environment is of potential importance. The human brain preattentively or automatically detects such changes. The mismatch negativity (MMN) of event-related potentials (ERPs) reflects this initial stage of auditory change detection. The origin of MMN is held to be cortical. The hippocampus is associated with a later generated P3a of ERPs reflecting involuntarily attention switches towards auditory changes that are high in magnitude. The evidence for this cortico-hippocampal dichotomy is scarce, however. To shed further light on this issue, auditory cortical and hippocampal-system (CA1, dentate gyrus, subiculum) local-field potentials were recorded in urethane-anesthetized rats. A rare tone in duration (deviant) was interspersed with a repeated tone (standard). Two standard-to-standard (SSI) and standard-to-deviant (SDI) intervals (200 ms vs. 500 ms) were applied in different combinations to vary the observability of responses resembling MMN (mismatch responses). Mismatch responses were observed at 51.5-89 ms with the 500-ms SSI coupled with the 200-ms SDI but not with the three remaining combinations. Most importantly, the responses appeared in both the auditory-cortical and hippocampal locations. The findings suggest that the hippocampus may play a role in (cortical) manifestation of MMN.Timo RuusuvirtaArto LipponenEeva PellinenMarkku PenttonenPiia AstikainenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54624 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timo Ruusuvirta Arto Lipponen Eeva Pellinen Markku Penttonen Piia Astikainen Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
description	Any change in the invariant aspects of the auditory environment is of potential importance. The human brain preattentively or automatically detects such changes. The mismatch negativity (MMN) of event-related potentials (ERPs) reflects this initial stage of auditory change detection. The origin of MMN is held to be cortical. The hippocampus is associated with a later generated P3a of ERPs reflecting involuntarily attention switches towards auditory changes that are high in magnitude. The evidence for this cortico-hippocampal dichotomy is scarce, however. To shed further light on this issue, auditory cortical and hippocampal-system (CA1, dentate gyrus, subiculum) local-field potentials were recorded in urethane-anesthetized rats. A rare tone in duration (deviant) was interspersed with a repeated tone (standard). Two standard-to-standard (SSI) and standard-to-deviant (SDI) intervals (200 ms vs. 500 ms) were applied in different combinations to vary the observability of responses resembling MMN (mismatch responses). Mismatch responses were observed at 51.5-89 ms with the 500-ms SSI coupled with the 200-ms SDI but not with the three remaining combinations. Most importantly, the responses appeared in both the auditory-cortical and hippocampal locations. The findings suggest that the hippocampus may play a role in (cortical) manifestation of MMN.
format	article
author	Timo Ruusuvirta Arto Lipponen Eeva Pellinen Markku Penttonen Piia Astikainen
author_facet	Timo Ruusuvirta Arto Lipponen Eeva Pellinen Markku Penttonen Piia Astikainen
author_sort	Timo Ruusuvirta
title	Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
title_short	Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
title_full	Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
title_fullStr	Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
title_full_unstemmed	Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
title_sort	auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/130a59e5e0d541508c8589e45f8b12ce
work_keys_str_mv	AT timoruusuvirta auditorycorticalandhippocampalsystemmismatchresponsestodurationdeviantsinurethaneanesthetizedrats AT artolipponen auditorycorticalandhippocampalsystemmismatchresponsestodurationdeviantsinurethaneanesthetizedrats AT eevapellinen auditorycorticalandhippocampalsystemmismatchresponsestodurationdeviantsinurethaneanesthetizedrats AT markkupenttonen auditorycorticalandhippocampalsystemmismatchresponsestodurationdeviantsinurethaneanesthetizedrats AT piiaastikainen auditorycorticalandhippocampalsystemmismatchresponsestodurationdeviantsinurethaneanesthetizedrats
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Auditory cortical and hippocampal-system mismatch responses to duration deviants in urethane-anesthetized rats.

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