Engineering circular RNA for potent and stable translation in eukaryotic cells

Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.

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Detalles Bibliográficos
Autores principales:	R. Alexander Wesselhoeft, Piotr S. Kowalski, Daniel G. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/130b5ea301d3466e9d0a07fec763a18b
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spelling	oai:doaj.org-article:130b5ea301d3466e9d0a07fec763a18b2021-12-02T15:33:46ZEngineering circular RNA for potent and stable translation in eukaryotic cells10.1038/s41467-018-05096-62041-1723https://doaj.org/article/130b5ea301d3466e9d0a07fec763a18b2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05096-6https://doaj.org/toc/2041-1723Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.R. Alexander WesselhoeftPiotr S. KowalskiDaniel G. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. Alexander Wesselhoeft Piotr S. Kowalski Daniel G. Anderson Engineering circular RNA for potent and stable translation in eukaryotic cells
description	Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.
format	article
author	R. Alexander Wesselhoeft Piotr S. Kowalski Daniel G. Anderson
author_facet	R. Alexander Wesselhoeft Piotr S. Kowalski Daniel G. Anderson
author_sort	R. Alexander Wesselhoeft
title	Engineering circular RNA for potent and stable translation in eukaryotic cells
title_short	Engineering circular RNA for potent and stable translation in eukaryotic cells
title_full	Engineering circular RNA for potent and stable translation in eukaryotic cells
title_fullStr	Engineering circular RNA for potent and stable translation in eukaryotic cells
title_full_unstemmed	Engineering circular RNA for potent and stable translation in eukaryotic cells
title_sort	engineering circular rna for potent and stable translation in eukaryotic cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/130b5ea301d3466e9d0a07fec763a18b
work_keys_str_mv	AT ralexanderwesselhoeft engineeringcircularrnaforpotentandstabletranslationineukaryoticcells AT piotrskowalski engineeringcircularrnaforpotentandstabletranslationineukaryoticcells AT danielganderson engineeringcircularrnaforpotentandstabletranslationineukaryoticcells
_version_	1718387005906223104

Engineering circular RNA for potent and stable translation in eukaryotic cells

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