Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study

Xianzhu Tu,1 Juanjuan Wang,2 Xuming Liu,3 Jiyong Zheng4 1Department of Psychiatry, Seventh People’s Hospital of Wenzhou City, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang,...

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Autores principales:	Tu XZ, Wang JJ, Liu XM, Zheng JY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Alcohol dependence Regional homogeneity Receiver operating characteristic Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/130bdbb077b04177acd70c3e76e52ca1
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spelling	oai:doaj.org-article:130bdbb077b04177acd70c3e76e52ca12021-12-02T02:31:34ZAberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study1178-2021https://doaj.org/article/130bdbb077b04177acd70c3e76e52ca12018-03-01T00:00:00Zhttps://www.dovepress.com/aberrant-regional-brain-activities-in-alcohol-dependence-a-functional--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xianzhu Tu,1 Juanjuan Wang,2 Xuming Liu,3 Jiyong Zheng4 1Department of Psychiatry, Seventh People’s Hospital of Wenzhou City, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Radiology, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Medical Imaging, The Affiliated Huai’an No 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China Objective: Whether moderate alcohol consumption has health benefits remains controversial, but the harmful effects of excessive alcohol consumption on behavior and brain function are well recognized. The aim of this study was to investigate alcohol-induced regional brain activities and their relationships with behavioral factors. Subjects and methods: A total of 29 alcohol-dependent subjects (9 females and 20 males) and 29 status-matched healthy controls (11 females and 18 males) were recruited. Severity of alcohol dependence questionnaire (SADQ) and alcohol use disorders identification test (AUDIT) were used to evaluate the severity of alcohol craving. Regional homogeneity (ReHo) analysis was used to explore the alcohol-induced regional brain changes. Receiver operating characteristic (ROC) curve was used to investigate the ability of regional brain activities to distinguish alcohol-dependent subjects from healthy controls. Pearson correlations were used to investigate the relationships between alcohol-induced ReHo differences and behavioral factors. Results: Alcohol-dependent subjects related to healthy controls showed higher ReHo areas in the right superior frontal gyrus (SFG), bilateral medial frontal gyrus (MFG), left precentral gyrus (PG), bilateral middle temporal gyrus (MTG), and right inferior temporal gyrus (ITG) and lower ReHo areas in the right cerebellum posterior lobe (CPL), left rectal gyrus (RG), and right cluster of pons and cerebellum anterior lobe (CAL). ROC curve revealed high area under the curve (AUC) values (mean ± SD: 0.864 ± 0.028; range: 0.828–0.911) of ReHo differences. Diagnostic analysis showed that these areas alone discriminated alcohol-dependent subjects from healthy controls with high degree of sensitivities (mean ± SD: 81.25% ± 11.49%; range: 62.5%–100%) and specificities (mean ± SD: 81.75% ± 12.36%; range: 67.5%–100%). Years of drink showed negative correlation with left RG (r = -0.493, p = 0.007), the same finding was shown between AUDIT and right CPL (r = -0.52, p = 0.004). Conclusion: Alcohol dependence is associated with aberrant regional activities in multiple brain areas. ReHo analysis may be a useful biological indicator for the detection of regional brain activities in individuals with alcohol dependence. Keywords: alcohol dependence, regional homogeneity, receiver operating characteristicTu XZWang JJLiu XMZheng JYDove Medical PressarticleAlcohol dependenceRegional homogeneityReceiver operating characteristicNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 847-853 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alcohol dependence Regional homogeneity Receiver operating characteristic Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Alcohol dependence Regional homogeneity Receiver operating characteristic Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tu XZ Wang JJ Liu XM Zheng JY Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
description	Xianzhu Tu,1 Juanjuan Wang,2 Xuming Liu,3 Jiyong Zheng4 1Department of Psychiatry, Seventh People’s Hospital of Wenzhou City, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Radiology, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Medical Imaging, The Affiliated Huai’an No 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China Objective: Whether moderate alcohol consumption has health benefits remains controversial, but the harmful effects of excessive alcohol consumption on behavior and brain function are well recognized. The aim of this study was to investigate alcohol-induced regional brain activities and their relationships with behavioral factors. Subjects and methods: A total of 29 alcohol-dependent subjects (9 females and 20 males) and 29 status-matched healthy controls (11 females and 18 males) were recruited. Severity of alcohol dependence questionnaire (SADQ) and alcohol use disorders identification test (AUDIT) were used to evaluate the severity of alcohol craving. Regional homogeneity (ReHo) analysis was used to explore the alcohol-induced regional brain changes. Receiver operating characteristic (ROC) curve was used to investigate the ability of regional brain activities to distinguish alcohol-dependent subjects from healthy controls. Pearson correlations were used to investigate the relationships between alcohol-induced ReHo differences and behavioral factors. Results: Alcohol-dependent subjects related to healthy controls showed higher ReHo areas in the right superior frontal gyrus (SFG), bilateral medial frontal gyrus (MFG), left precentral gyrus (PG), bilateral middle temporal gyrus (MTG), and right inferior temporal gyrus (ITG) and lower ReHo areas in the right cerebellum posterior lobe (CPL), left rectal gyrus (RG), and right cluster of pons and cerebellum anterior lobe (CAL). ROC curve revealed high area under the curve (AUC) values (mean ± SD: 0.864 ± 0.028; range: 0.828–0.911) of ReHo differences. Diagnostic analysis showed that these areas alone discriminated alcohol-dependent subjects from healthy controls with high degree of sensitivities (mean ± SD: 81.25% ± 11.49%; range: 62.5%–100%) and specificities (mean ± SD: 81.75% ± 12.36%; range: 67.5%–100%). Years of drink showed negative correlation with left RG (r = -0.493, p = 0.007), the same finding was shown between AUDIT and right CPL (r = -0.52, p = 0.004). Conclusion: Alcohol dependence is associated with aberrant regional activities in multiple brain areas. ReHo analysis may be a useful biological indicator for the detection of regional brain activities in individuals with alcohol dependence. Keywords: alcohol dependence, regional homogeneity, receiver operating characteristic
format	article
author	Tu XZ Wang JJ Liu XM Zheng JY
author_facet	Tu XZ Wang JJ Liu XM Zheng JY
author_sort	Tu XZ
title	Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
title_short	Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
title_full	Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
title_fullStr	Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
title_full_unstemmed	Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
title_sort	aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/130bdbb077b04177acd70c3e76e52ca1
work_keys_str_mv	AT tuxz aberrantregionalbrainactivitiesinalcoholdependenceafunctionalmagneticresonanceimagingstudy AT wangjj aberrantregionalbrainactivitiesinalcoholdependenceafunctionalmagneticresonanceimagingstudy AT liuxm aberrantregionalbrainactivitiesinalcoholdependenceafunctionalmagneticresonanceimagingstudy AT zhengjy aberrantregionalbrainactivitiesinalcoholdependenceafunctionalmagneticresonanceimagingstudy
_version_	1718402391521361920

Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study

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