Affective theory of mind in Parkinson’s disease: the effect of cognitive performance
Ana-Maria Romosan,1,* Liana Dehelean,1,* Radu-Stefan Romosan,1,* Minodora Andor,2 Ana Cristina Bredicean,1 Mihaela Adriana Simu31Department of Neurosciences, Discipline of Psychiatry, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Department of Internal...
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Dove Medical Press
2019
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oai:doaj.org-article:130d2c96fda442c780ab00806025b3a02021-12-02T09:29:15ZAffective theory of mind in Parkinson’s disease: the effect of cognitive performance1178-2021https://doaj.org/article/130d2c96fda442c780ab00806025b3a02019-08-01T00:00:00Zhttps://www.dovepress.com/affective-theory-of-mind-in-parkinsonrsquos-disease-the-effect-of-cogn-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ana-Maria Romosan,1,* Liana Dehelean,1,* Radu-Stefan Romosan,1,* Minodora Andor,2 Ana Cristina Bredicean,1 Mihaela Adriana Simu31Department of Neurosciences, Discipline of Psychiatry, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Department of Internal Medicine, Discipline of Medical Semiology II, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 3Department of Neurosciences, Discipline of Neurology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaCorrespondence: Liana DeheleanDepartment of Neurosciences, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, Timisoara 300041, RomaniaTel +40 72 498 1888Fax +40 25 649 0626Email dehelean.liana@gmail.com*These authors contributed equally to this workPurpose: Among other non-motor symptoms, theory of mind (ToM), the ability to recognize, understand and infer others’ mental states, beliefs, intents and wishes, has been shown to deteriorate during the course of Parkinson’s disease (PD). It has been speculated that ToM impairments could be related to cognitive deficits in PD. However, the current state of literature suggests that there is heterogeneity regarding the involvement of cognitive functioning in the relationship of PD and ToM. The study aimed to measure affective ToM abilities and cognitive performance in a sample of PD patients, to explore the link between affective ToM abilities and cognitive status, and to examine the impact of PD on affective ToM through the mediator effect of cognitive performance.Patients and methods: Sixty-five patients diagnosed with idiopathic PD and 51 healthy controls matched for age, gender and educational level completed a visual affective ToM task (Reading the Mind in the Eyes – RMET), cognitive performance was evaluated with Montreal Cognitive Assessment, and psychiatric symptoms were measured with BPRS-E (Brief Psychiatric Rating Scale).Results: Affective ToM abilities were preserved in early PD patients, declining as the disease progressed. Deficits in cognitive functioning predicted deficiencies in affective ToM. Although attention (AT), executive functions (EF) and visuospatial abilities (VSA) together mediated the relationship between PD and affective ToM, only VSA impairment had a specific negative impact on affective ToM. Moreover, 41% of the total effect of attention and executive functions on affective ToM was mediated by visuospatial skills.Conclusion: Cognitive performance may have an impact on the relationship between PD and affective ToM through the involvement of VSA. The influence of AT and EF in this relationship appears to be also exerted by PD patients’ VSA.Keywords: Parkinson’s disease, cognitive functions, social cognition, visuospatial abilities, executive functionsRomosan AMDehelean LRomosan RSAndor MBredicean ACSimu MADove Medical PressarticleParkinson’s diseasecognitive functionssocial cognitionvisuospatial abilitiesexecutive functionsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2521-2535 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Parkinson’s disease cognitive functions social cognition visuospatial abilities executive functions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Parkinson’s disease cognitive functions social cognition visuospatial abilities executive functions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Romosan AM Dehelean L Romosan RS Andor M Bredicean AC Simu MA Affective theory of mind in Parkinson’s disease: the effect of cognitive performance |
| description |
Ana-Maria Romosan,1,* Liana Dehelean,1,* Radu-Stefan Romosan,1,* Minodora Andor,2 Ana Cristina Bredicean,1 Mihaela Adriana Simu31Department of Neurosciences, Discipline of Psychiatry, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Department of Internal Medicine, Discipline of Medical Semiology II, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 3Department of Neurosciences, Discipline of Neurology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaCorrespondence: Liana DeheleanDepartment of Neurosciences, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, Timisoara 300041, RomaniaTel +40 72 498 1888Fax +40 25 649 0626Email dehelean.liana@gmail.com*These authors contributed equally to this workPurpose: Among other non-motor symptoms, theory of mind (ToM), the ability to recognize, understand and infer others’ mental states, beliefs, intents and wishes, has been shown to deteriorate during the course of Parkinson’s disease (PD). It has been speculated that ToM impairments could be related to cognitive deficits in PD. However, the current state of literature suggests that there is heterogeneity regarding the involvement of cognitive functioning in the relationship of PD and ToM. The study aimed to measure affective ToM abilities and cognitive performance in a sample of PD patients, to explore the link between affective ToM abilities and cognitive status, and to examine the impact of PD on affective ToM through the mediator effect of cognitive performance.Patients and methods: Sixty-five patients diagnosed with idiopathic PD and 51 healthy controls matched for age, gender and educational level completed a visual affective ToM task (Reading the Mind in the Eyes – RMET), cognitive performance was evaluated with Montreal Cognitive Assessment, and psychiatric symptoms were measured with BPRS-E (Brief Psychiatric Rating Scale).Results: Affective ToM abilities were preserved in early PD patients, declining as the disease progressed. Deficits in cognitive functioning predicted deficiencies in affective ToM. Although attention (AT), executive functions (EF) and visuospatial abilities (VSA) together mediated the relationship between PD and affective ToM, only VSA impairment had a specific negative impact on affective ToM. Moreover, 41% of the total effect of attention and executive functions on affective ToM was mediated by visuospatial skills.Conclusion: Cognitive performance may have an impact on the relationship between PD and affective ToM through the involvement of VSA. The influence of AT and EF in this relationship appears to be also exerted by PD patients’ VSA.Keywords: Parkinson’s disease, cognitive functions, social cognition, visuospatial abilities, executive functions |
| format |
article |
| author |
Romosan AM Dehelean L Romosan RS Andor M Bredicean AC Simu MA |
| author_facet |
Romosan AM Dehelean L Romosan RS Andor M Bredicean AC Simu MA |
| author_sort |
Romosan AM |
| title |
Affective theory of mind in Parkinson’s disease: the effect of cognitive performance |
| title_short |
Affective theory of mind in Parkinson’s disease: the effect of cognitive performance |
| title_full |
Affective theory of mind in Parkinson’s disease: the effect of cognitive performance |
| title_fullStr |
Affective theory of mind in Parkinson’s disease: the effect of cognitive performance |
| title_full_unstemmed |
Affective theory of mind in Parkinson’s disease: the effect of cognitive performance |
| title_sort |
affective theory of mind in parkinson’s disease: the effect of cognitive performance |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/130d2c96fda442c780ab00806025b3a0 |
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