Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

COVID-19 is a serious pandemic threat to public health, but insights on the pathophysiological and immunological conditions are only emerging. Here the authors use multi-color flow cytometry to characterize CD4+ and CD8+ T cells in peripheral blood from 39 COVID-19 patients in Italy to report altere...

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Autores principales: Sara De Biasi, Marianna Meschiari, Lara Gibellini, Caterina Bellinazzi, Rebecca Borella, Lucia Fidanza, Licia Gozzi, Anna Iannone, Domenico Lo Tartaro, Marco Mattioli, Annamaria Paolini, Marianna Menozzi, Jovana Milić, Giacomo Franceschi, Riccardo Fantini, Roberto Tonelli, Marco Sita, Mario Sarti, Tommaso Trenti, Lucio Brugioni, Luca Cicchetti, Fabio Facchinetti, Antonello Pietrangelo, Enrico Clini, Massimo Girardis, Giovanni Guaraldi, Cristina Mussini, Andrea Cossarizza
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/13104f0d28544740ae120c92d91f5bd4
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spelling oai:doaj.org-article:13104f0d28544740ae120c92d91f5bd42021-12-02T15:39:52ZMarked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia10.1038/s41467-020-17292-42041-1723https://doaj.org/article/13104f0d28544740ae120c92d91f5bd42020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17292-4https://doaj.org/toc/2041-1723COVID-19 is a serious pandemic threat to public health, but insights on the pathophysiological and immunological conditions are only emerging. Here the authors use multi-color flow cytometry to characterize CD4+ and CD8+ T cells in peripheral blood from 39 COVID-19 patients in Italy to report altered T cell activation, function and polarization.Sara De BiasiMarianna MeschiariLara GibelliniCaterina BellinazziRebecca BorellaLucia FidanzaLicia GozziAnna IannoneDomenico Lo TartaroMarco MattioliAnnamaria PaoliniMarianna MenozziJovana MilićGiacomo FranceschiRiccardo FantiniRoberto TonelliMarco SitaMario SartiTommaso TrentiLucio BrugioniLuca CicchettiFabio FacchinettiAntonello PietrangeloEnrico CliniMassimo GirardisGiovanni GuaraldiCristina MussiniAndrea CossarizzaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sara De Biasi
Marianna Meschiari
Lara Gibellini
Caterina Bellinazzi
Rebecca Borella
Lucia Fidanza
Licia Gozzi
Anna Iannone
Domenico Lo Tartaro
Marco Mattioli
Annamaria Paolini
Marianna Menozzi
Jovana Milić
Giacomo Franceschi
Riccardo Fantini
Roberto Tonelli
Marco Sita
Mario Sarti
Tommaso Trenti
Lucio Brugioni
Luca Cicchetti
Fabio Facchinetti
Antonello Pietrangelo
Enrico Clini
Massimo Girardis
Giovanni Guaraldi
Cristina Mussini
Andrea Cossarizza
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
description COVID-19 is a serious pandemic threat to public health, but insights on the pathophysiological and immunological conditions are only emerging. Here the authors use multi-color flow cytometry to characterize CD4+ and CD8+ T cells in peripheral blood from 39 COVID-19 patients in Italy to report altered T cell activation, function and polarization.
format article
author Sara De Biasi
Marianna Meschiari
Lara Gibellini
Caterina Bellinazzi
Rebecca Borella
Lucia Fidanza
Licia Gozzi
Anna Iannone
Domenico Lo Tartaro
Marco Mattioli
Annamaria Paolini
Marianna Menozzi
Jovana Milić
Giacomo Franceschi
Riccardo Fantini
Roberto Tonelli
Marco Sita
Mario Sarti
Tommaso Trenti
Lucio Brugioni
Luca Cicchetti
Fabio Facchinetti
Antonello Pietrangelo
Enrico Clini
Massimo Girardis
Giovanni Guaraldi
Cristina Mussini
Andrea Cossarizza
author_facet Sara De Biasi
Marianna Meschiari
Lara Gibellini
Caterina Bellinazzi
Rebecca Borella
Lucia Fidanza
Licia Gozzi
Anna Iannone
Domenico Lo Tartaro
Marco Mattioli
Annamaria Paolini
Marianna Menozzi
Jovana Milić
Giacomo Franceschi
Riccardo Fantini
Roberto Tonelli
Marco Sita
Mario Sarti
Tommaso Trenti
Lucio Brugioni
Luca Cicchetti
Fabio Facchinetti
Antonello Pietrangelo
Enrico Clini
Massimo Girardis
Giovanni Guaraldi
Cristina Mussini
Andrea Cossarizza
author_sort Sara De Biasi
title Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
title_short Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
title_full Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
title_fullStr Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
title_full_unstemmed Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
title_sort marked t cell activation, senescence, exhaustion and skewing towards th17 in patients with covid-19 pneumonia
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/13104f0d28544740ae120c92d91f5bd4
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