Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

COVID-19 is a serious pandemic threat to public health, but insights on the pathophysiological and immunological conditions are only emerging. Here the authors use multi-color flow cytometry to characterize CD4+ and CD8+ T cells in peripheral blood from 39 COVID-19 patients in Italy to report altere...

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Main Authors: Sara De Biasi, Marianna Meschiari, Lara Gibellini, Caterina Bellinazzi, Rebecca Borella, Lucia Fidanza, Licia Gozzi, Anna Iannone, Domenico Lo Tartaro, Marco Mattioli, Annamaria Paolini, Marianna Menozzi, Jovana Milić, Giacomo Franceschi, Riccardo Fantini, Roberto Tonelli, Marco Sita, Mario Sarti, Tommaso Trenti, Lucio Brugioni, Luca Cicchetti, Fabio Facchinetti, Antonello Pietrangelo, Enrico Clini, Massimo Girardis, Giovanni Guaraldi, Cristina Mussini, Andrea Cossarizza
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/13104f0d28544740ae120c92d91f5bd4
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