Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small molecule inhibitors, which will facilitate the devel...

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Autores principales:	Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50
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spelling	oai:doaj.org-article:13114a6254b94cd5a8f05eeabf842c502021-12-02T17:01:40ZStructure and inhibition mechanism of the catalytic domain of human squalene epoxidase10.1038/s41467-018-07928-x2041-1723https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c502019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07928-xhttps://doaj.org/toc/2041-1723Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small molecule inhibitors, which will facilitate the development of next-generation SQLE inhibitors.Anil K. PadyanaStefan GrossLei JinGiovanni CianchettaRohini NarayanaswamyFeng WangRui WangCheng FangXiaobing LvScott A. BillerLenny DangChristopher E. MahoneyNelamangala NagarajaDavid PirmanZhihua SuiJaneta Popovici-MullerGromoslaw A. SmolenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anil K. Padyana Stefan Gross Lei Jin Giovanni Cianchetta Rohini Narayanaswamy Feng Wang Rui Wang Cheng Fang Xiaobing Lv Scott A. Biller Lenny Dang Christopher E. Mahoney Nelamangala Nagaraja David Pirman Zhihua Sui Janeta Popovici-Muller Gromoslaw A. Smolen Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
description	Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small molecule inhibitors, which will facilitate the development of next-generation SQLE inhibitors.
format	article
author	Anil K. Padyana Stefan Gross Lei Jin Giovanni Cianchetta Rohini Narayanaswamy Feng Wang Rui Wang Cheng Fang Xiaobing Lv Scott A. Biller Lenny Dang Christopher E. Mahoney Nelamangala Nagaraja David Pirman Zhihua Sui Janeta Popovici-Muller Gromoslaw A. Smolen
author_facet	Anil K. Padyana Stefan Gross Lei Jin Giovanni Cianchetta Rohini Narayanaswamy Feng Wang Rui Wang Cheng Fang Xiaobing Lv Scott A. Biller Lenny Dang Christopher E. Mahoney Nelamangala Nagaraja David Pirman Zhihua Sui Janeta Popovici-Muller Gromoslaw A. Smolen
author_sort	Anil K. Padyana
title	Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
title_short	Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
title_full	Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
title_fullStr	Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
title_full_unstemmed	Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
title_sort	structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50
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Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

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