Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients

Abstract We hypothesised that the established association of endothelial lipase (EL) plasma levels with atherogenic lipid profile is altered in acute heart failure (AHF) and additionally affected by overlapping metabolic syndrome (MetS). We examined the association of EL plasma levels and lipid/lipo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ines Potočnjak, Matias Trbušić, Sanda Dokoza Terešak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Beate Tiran, Gunther Marsche, Vesna Degoricija, Saša Frank
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1314f283a1a84551ba7671ed31695a8d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1314f283a1a84551ba7671ed31695a8d
record_format	dspace
spelling	oai:doaj.org-article:1314f283a1a84551ba7671ed31695a8d2021-12-02T12:32:33ZMetabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients10.1038/s41598-017-01367-22045-2322https://doaj.org/article/1314f283a1a84551ba7671ed31695a8d2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01367-2https://doaj.org/toc/2045-2322Abstract We hypothesised that the established association of endothelial lipase (EL) plasma levels with atherogenic lipid profile is altered in acute heart failure (AHF) and additionally affected by overlapping metabolic syndrome (MetS). We examined the association of EL plasma levels and lipid/lipoprotein plasma levels in AHF patients without and with overlapping MetS. The study was performed as a single-centre, observational study on 152 AHF patients, out of which 85 had overlapping MetS. In the no-MetS group, EL plasma levels were significantly positively correlated with plasma levels of atherogenic lipids/lipoproteins, including total cholesterol, low-density lipoprotein (LDL)-cholesterol, total LDL particles and triglycerides, but also with plasma levels of antiatherogenic high-density lipoprotein (HDL)-cholesterol, total HDL particles and small HDL particles. In the MetS group, EL plasma levels were positively correlated with triglyceride and small LDL-particle levels, and significantly negatively correlated with plasma levels of large HDL particles as well as with LDL- and HDL-particle size, respectively. EL- and lipid/lipoprotein- plasma levels were different in the no-MetS patients, compared to MetS patients. The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF.Ines PotočnjakMatias TrbušićSanda Dokoza TerešakBojana RadulovićGudrun PregartnerAndrea BergholdBeate TiranGunther MarscheVesna DegoricijaSaša FrankNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ines Potočnjak Matias Trbušić Sanda Dokoza Terešak Bojana Radulović Gudrun Pregartner Andrea Berghold Beate Tiran Gunther Marsche Vesna Degoricija Saša Frank Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients
description	Abstract We hypothesised that the established association of endothelial lipase (EL) plasma levels with atherogenic lipid profile is altered in acute heart failure (AHF) and additionally affected by overlapping metabolic syndrome (MetS). We examined the association of EL plasma levels and lipid/lipoprotein plasma levels in AHF patients without and with overlapping MetS. The study was performed as a single-centre, observational study on 152 AHF patients, out of which 85 had overlapping MetS. In the no-MetS group, EL plasma levels were significantly positively correlated with plasma levels of atherogenic lipids/lipoproteins, including total cholesterol, low-density lipoprotein (LDL)-cholesterol, total LDL particles and triglycerides, but also with plasma levels of antiatherogenic high-density lipoprotein (HDL)-cholesterol, total HDL particles and small HDL particles. In the MetS group, EL plasma levels were positively correlated with triglyceride and small LDL-particle levels, and significantly negatively correlated with plasma levels of large HDL particles as well as with LDL- and HDL-particle size, respectively. EL- and lipid/lipoprotein- plasma levels were different in the no-MetS patients, compared to MetS patients. The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF.
format	article
author	Ines Potočnjak Matias Trbušić Sanda Dokoza Terešak Bojana Radulović Gudrun Pregartner Andrea Berghold Beate Tiran Gunther Marsche Vesna Degoricija Saša Frank
author_facet	Ines Potočnjak Matias Trbušić Sanda Dokoza Terešak Bojana Radulović Gudrun Pregartner Andrea Berghold Beate Tiran Gunther Marsche Vesna Degoricija Saša Frank
author_sort	Ines Potočnjak
title	Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients
title_short	Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients
title_full	Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients
title_fullStr	Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients
title_full_unstemmed	Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients
title_sort	metabolic syndrome modulates association between endothelial lipase and lipid/lipoprotein plasma levels in acute heart failure patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1314f283a1a84551ba7671ed31695a8d
work_keys_str_mv	AT inespotocnjak metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT matiastrbusic metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT sandadokozateresak metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT bojanaradulovic metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT gudrunpregartner metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT andreaberghold metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT beatetiran metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT gunthermarsche metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT vesnadegoricija metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients AT sasafrank metabolicsyndromemodulatesassociationbetweenendotheliallipaseandlipidlipoproteinplasmalevelsinacuteheartfailurepatients
_version_	1718394022706282496

Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients

Ejemplares similares