Hematological and biochemical status of βeta-thalassemia major patients in Koya city.

Thalassemia major is a severe anemia that requires blood transfusions. In this study, we searched into the hematological and biochemical status of βeta-thalassemia major patients in Koya. Hematological analysis revealed severe anemia in βeta-thalassemia patients when compared to controls. The hemogl...

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Autores principales:	Kochar Khasro Saleh, Ismail Salih Kakey
Formato:	article
Lenguaje:	EN
Publicado:	Salahaddin University-Erbil 2021
Materias:	anemia βeta-thalassemia hematology biochemistry Technology T Science Q
Acceso en línea:	https://doaj.org/article/1315a992957c421f8466db6cacbdd0b8
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spelling	oai:doaj.org-article:1315a992957c421f8466db6cacbdd0b82021-11-07T06:20:04ZHematological and biochemical status of βeta-thalassemia major patients in Koya city.10.21271/ZJPAS.33.5.92218-02302412-3986https://doaj.org/article/1315a992957c421f8466db6cacbdd0b82021-10-01T00:00:00Zhttps://zancojournals.su.edu.krd/index.php/JPAS/article/view/3688https://doaj.org/toc/2218-0230https://doaj.org/toc/2412-3986Thalassemia major is a severe anemia that requires blood transfusions. In this study, we searched into the hematological and biochemical status of βeta-thalassemia major patients in Koya. Hematological analysis revealed severe anemia in βeta-thalassemia patients when compared to controls. The hemoglobin levels in patients were less than 30% of that of controls. Furthermore, patients had a significant leukocytosis compared to the controls. Red blood cell incidences are decreased except RDW, which were Hct includes (23.8±2.9 % vs. 34.6±2.3 %), MCV (71.8±7.1 fl vs. 77.5±4.1 fl), MCH (20.2±2.4 pg vs. 23.5 ± 2.2 pg) and MCHC (30.8±0.7 g/dl vs. 30.1±1.2 g/dl), while RDW % (20.5±9.7 % vs. 14.2±2.5 %). The linear regression analysis showed non-correlation between iron overload with RBC, WBC, and red blood cell incidences (hemoglobin (Hb), hematocrit (Hct), mean corpuscle hemoglobin (MCH), and mean corpuscle hemoglobin concentration (MCHC), while PLT count, mean corpuscular volume (MCV) and red cell distribution width (RDW) showed a significant positive correlation with iron overload. The biochemical characteristics of the patients showed a significant increase in the levels of liver enzymatic parameters, ALP, ALT, and AST as compared to controls.Kochar Khasro SalehIsmail Salih KakeySalahaddin University-Erbilarticleanemiaβeta-thalassemiahematologybiochemistryTechnologyTScienceQENZanco Journal of Pure and Applied Sciences, Vol 33, Iss 5, Pp 76-84 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anemia βeta-thalassemia hematology biochemistry Technology T Science Q
spellingShingle	anemia βeta-thalassemia hematology biochemistry Technology T Science Q Kochar Khasro Saleh Ismail Salih Kakey Hematological and biochemical status of βeta-thalassemia major patients in Koya city.
description	Thalassemia major is a severe anemia that requires blood transfusions. In this study, we searched into the hematological and biochemical status of βeta-thalassemia major patients in Koya. Hematological analysis revealed severe anemia in βeta-thalassemia patients when compared to controls. The hemoglobin levels in patients were less than 30% of that of controls. Furthermore, patients had a significant leukocytosis compared to the controls. Red blood cell incidences are decreased except RDW, which were Hct includes (23.8±2.9 % vs. 34.6±2.3 %), MCV (71.8±7.1 fl vs. 77.5±4.1 fl), MCH (20.2±2.4 pg vs. 23.5 ± 2.2 pg) and MCHC (30.8±0.7 g/dl vs. 30.1±1.2 g/dl), while RDW % (20.5±9.7 % vs. 14.2±2.5 %). The linear regression analysis showed non-correlation between iron overload with RBC, WBC, and red blood cell incidences (hemoglobin (Hb), hematocrit (Hct), mean corpuscle hemoglobin (MCH), and mean corpuscle hemoglobin concentration (MCHC), while PLT count, mean corpuscular volume (MCV) and red cell distribution width (RDW) showed a significant positive correlation with iron overload. The biochemical characteristics of the patients showed a significant increase in the levels of liver enzymatic parameters, ALP, ALT, and AST as compared to controls.
format	article
author	Kochar Khasro Saleh Ismail Salih Kakey
author_facet	Kochar Khasro Saleh Ismail Salih Kakey
author_sort	Kochar Khasro Saleh
title	Hematological and biochemical status of βeta-thalassemia major patients in Koya city.
title_short	Hematological and biochemical status of βeta-thalassemia major patients in Koya city.
title_full	Hematological and biochemical status of βeta-thalassemia major patients in Koya city.
title_fullStr	Hematological and biochemical status of βeta-thalassemia major patients in Koya city.
title_full_unstemmed	Hematological and biochemical status of βeta-thalassemia major patients in Koya city.
title_sort	hematological and biochemical status of βeta-thalassemia major patients in koya city.
publisher	Salahaddin University-Erbil
publishDate	2021
url	https://doaj.org/article/1315a992957c421f8466db6cacbdd0b8
work_keys_str_mv	AT kocharkhasrosaleh hematologicalandbiochemicalstatusofbetathalassemiamajorpatientsinkoyacity AT ismailsalihkakey hematologicalandbiochemicalstatusofbetathalassemiamajorpatientsinkoyacity
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Hematological and biochemical status of βeta-thalassemia major patients in Koya city.

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