Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer

Background and Objectives: This study aims to explore the safety of preoperative chemotherapy and clarify whether preoperative chemotherapy with oxaliplatin + S-1 (SOX) regimen and its adverse events are associated with higher risks of postoperative complications.Methods: We included consecutive pat...

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Autores principales:	Zhouqiao Wu, Yiding Wang, Shiyang Hou, Qi Wang, Bailong Li, Xiangji Ying, Shuangxi Li, Ziyu Li, Jiafu Ji
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	postoperative complications adverse events preoperative chemotherapy gastric cancer propensity score matching Surgery RD1-811
Acceso en línea:	https://doaj.org/article/1316a869932c497781ab18b3c93ead88
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spelling	oai:doaj.org-article:1316a869932c497781ab18b3c93ead882021-12-02T09:53:53ZCorrelative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer2296-875X10.3389/fsurg.2021.768243https://doaj.org/article/1316a869932c497781ab18b3c93ead882021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.768243/fullhttps://doaj.org/toc/2296-875XBackground and Objectives: This study aims to explore the safety of preoperative chemotherapy and clarify whether preoperative chemotherapy with oxaliplatin + S-1 (SOX) regimen and its adverse events are associated with higher risks of postoperative complications.Methods: We included consecutive patients with gastric cancer who underwent gastrectomy in our department between July 1 2018, and January 31 2020. Patients with preoperative SOX regimen chemotherapy were included in the analysis.Results: In the 343 included patients, 77 cases underwent preoperative chemotherapy. In total, surgical complications were found in 117 patients (34.1%), and there was no significant difference between the patients with and without preoperative chemotherapy before and after propensity score matching (p > 0.05, respectively). Multivariate analysis showed that preoperative comorbidities (p = 0.026) and the preoperative cT4b (p = 0.028) were independent risk factors in postoperative complications. In patients with preoperative chemotherapy, neither the occurrence of adverse events nor their severity was associated with postoperative complications (p > 0.05). However, the patients who received five to six cycles were more prone to postoperative complications than those who received three to four cycles (62.5 vs. 27.9%, OR = 4.306, 95% Cl = 1.282–14.464, p = 0.018).Conclusions: Occurrence of postoperative complications was not influenced by preoperative SOX chemotherapy. However, increased cycles of chemotherapy may lead to higher incidence of postoperative complications.Zhouqiao WuYiding WangShiyang HouQi WangBailong LiXiangji YingShuangxi LiZiyu LiJiafu JiFrontiers Media S.A.articlepostoperative complicationsadverse eventspreoperative chemotherapygastric cancerpropensity score matchingSurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	postoperative complications adverse events preoperative chemotherapy gastric cancer propensity score matching Surgery RD1-811
spellingShingle	postoperative complications adverse events preoperative chemotherapy gastric cancer propensity score matching Surgery RD1-811 Zhouqiao Wu Yiding Wang Shiyang Hou Qi Wang Bailong Li Xiangji Ying Shuangxi Li Ziyu Li Jiafu Ji Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer
description	Background and Objectives: This study aims to explore the safety of preoperative chemotherapy and clarify whether preoperative chemotherapy with oxaliplatin + S-1 (SOX) regimen and its adverse events are associated with higher risks of postoperative complications.Methods: We included consecutive patients with gastric cancer who underwent gastrectomy in our department between July 1 2018, and January 31 2020. Patients with preoperative SOX regimen chemotherapy were included in the analysis.Results: In the 343 included patients, 77 cases underwent preoperative chemotherapy. In total, surgical complications were found in 117 patients (34.1%), and there was no significant difference between the patients with and without preoperative chemotherapy before and after propensity score matching (p > 0.05, respectively). Multivariate analysis showed that preoperative comorbidities (p = 0.026) and the preoperative cT4b (p = 0.028) were independent risk factors in postoperative complications. In patients with preoperative chemotherapy, neither the occurrence of adverse events nor their severity was associated with postoperative complications (p > 0.05). However, the patients who received five to six cycles were more prone to postoperative complications than those who received three to four cycles (62.5 vs. 27.9%, OR = 4.306, 95% Cl = 1.282–14.464, p = 0.018).Conclusions: Occurrence of postoperative complications was not influenced by preoperative SOX chemotherapy. However, increased cycles of chemotherapy may lead to higher incidence of postoperative complications.
format	article
author	Zhouqiao Wu Yiding Wang Shiyang Hou Qi Wang Bailong Li Xiangji Ying Shuangxi Li Ziyu Li Jiafu Ji
author_facet	Zhouqiao Wu Yiding Wang Shiyang Hou Qi Wang Bailong Li Xiangji Ying Shuangxi Li Ziyu Li Jiafu Ji
author_sort	Zhouqiao Wu
title	Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer
title_short	Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer
title_full	Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer
title_fullStr	Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer
title_full_unstemmed	Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer
title_sort	correlative analysis between adverse events of preoperative chemotherapy and postoperative complications of gastric cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1316a869932c497781ab18b3c93ead88
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_version_	1718397928857403392

Correlative Analysis Between Adverse Events of Preoperative Chemotherapy and Postoperative Complications of Gastric Cancer

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