Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 forIl9promoter binding and skewing these cells towards a Th1 phenotype, an effect that reduces asthmatic inflammation in mice.
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Nature Portfolio
2017
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oai:doaj.org-article:13172fb84a7445059a0849047683d7fa2021-12-02T14:41:11ZReciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF410.1038/ncomms153662041-1723https://doaj.org/article/13172fb84a7445059a0849047683d7fa2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15366https://doaj.org/toc/2041-1723IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 forIl9promoter binding and skewing these cells towards a Th1 phenotype, an effect that reduces asthmatic inflammation in mice.Lucia Campos CarrascosaMatthias KleinYohko KitagawaChristina LückelFederico MariniAnika KönigAnna GuralnikHartmann RaiferStefanie Hagner-BenesDiana RädlerAndreas BöckCholho KangMichael LohoffHolger GarnBianca SchaubFriederike Berberich-SiebeltShimon SakaguchiTobias BoppMagdalena HuberNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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| collection |
DOAJ |
| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Lucia Campos Carrascosa Matthias Klein Yohko Kitagawa Christina Lückel Federico Marini Anika König Anna Guralnik Hartmann Raifer Stefanie Hagner-Benes Diana Rädler Andreas Böck Cholho Kang Michael Lohoff Holger Garn Bianca Schaub Friederike Berberich-Siebelt Shimon Sakaguchi Tobias Bopp Magdalena Huber Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 |
| description |
IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 forIl9promoter binding and skewing these cells towards a Th1 phenotype, an effect that reduces asthmatic inflammation in mice. |
| format |
article |
| author |
Lucia Campos Carrascosa Matthias Klein Yohko Kitagawa Christina Lückel Federico Marini Anika König Anna Guralnik Hartmann Raifer Stefanie Hagner-Benes Diana Rädler Andreas Böck Cholho Kang Michael Lohoff Holger Garn Bianca Schaub Friederike Berberich-Siebelt Shimon Sakaguchi Tobias Bopp Magdalena Huber |
| author_facet |
Lucia Campos Carrascosa Matthias Klein Yohko Kitagawa Christina Lückel Federico Marini Anika König Anna Guralnik Hartmann Raifer Stefanie Hagner-Benes Diana Rädler Andreas Böck Cholho Kang Michael Lohoff Holger Garn Bianca Schaub Friederike Berberich-Siebelt Shimon Sakaguchi Tobias Bopp Magdalena Huber |
| author_sort |
Lucia Campos Carrascosa |
| title |
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 |
| title_short |
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 |
| title_full |
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 |
| title_fullStr |
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 |
| title_full_unstemmed |
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 |
| title_sort |
reciprocal regulation of the il9 locus by counteracting activities of transcription factors irf1 and irf4 |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/13172fb84a7445059a0849047683d7fa |
| work_keys_str_mv |
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| _version_ |
1718389975132667904 |