Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals

Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in bacterial physiology and virulence. Recently, the...

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Autores principales:	Rieko Imae, Hiroshi Manya, Tamao Endo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glycerol phosphate (GroP) α-dystroglycan (α-DG) core M3-type glycan CDP-glycerol (CDP-Gro) cytidylyltransferase Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/13175f7887cc4a1db2b0afc7890eb03c
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spelling	oai:doaj.org-article:13175f7887cc4a1db2b0afc7890eb03c2021-11-11T18:38:06ZBiosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals10.3390/molecules262166751420-3049https://doaj.org/article/13175f7887cc4a1db2b0afc7890eb03c2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6675https://doaj.org/toc/1420-3049Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in bacterial physiology and virulence. Recently, the first identification of a GroP-containing glycan in mammals was reported as a variant form of <i>O</i>-mannosyl glycan on α-dystroglycan (α-DG). However, the biological significance of such GroP modification remains largely unknown. In this review, we provide an overview of this new discovery of GroP-containing glycan in mammals and then outline the recent progress in elucidating the biosynthetic mechanisms of GroP-containing glycans on α-DG. In addition, we discuss the potential biological role of GroP modification along with the challenges and prospects for further research. The progress in this newly identified glycan modification will provide insights into the phylogenetic implications of glycan.Rieko ImaeHiroshi ManyaTamao EndoMDPI AGarticleglycerol phosphate (GroP)α-dystroglycan (α-DG)core M3-type glycanCDP-glycerol (CDP-Gro)cytidylyltransferaseOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6675, p 6675 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycerol phosphate (GroP) α-dystroglycan (α-DG) core M3-type glycan CDP-glycerol (CDP-Gro) cytidylyltransferase Organic chemistry QD241-441
spellingShingle	glycerol phosphate (GroP) α-dystroglycan (α-DG) core M3-type glycan CDP-glycerol (CDP-Gro) cytidylyltransferase Organic chemistry QD241-441 Rieko Imae Hiroshi Manya Tamao Endo Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
description	Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls. These glycopolymers comprising GroP play crucial roles in bacterial physiology and virulence. Recently, the first identification of a GroP-containing glycan in mammals was reported as a variant form of <i>O</i>-mannosyl glycan on α-dystroglycan (α-DG). However, the biological significance of such GroP modification remains largely unknown. In this review, we provide an overview of this new discovery of GroP-containing glycan in mammals and then outline the recent progress in elucidating the biosynthetic mechanisms of GroP-containing glycans on α-DG. In addition, we discuss the potential biological role of GroP modification along with the challenges and prospects for further research. The progress in this newly identified glycan modification will provide insights into the phylogenetic implications of glycan.
format	article
author	Rieko Imae Hiroshi Manya Tamao Endo
author_facet	Rieko Imae Hiroshi Manya Tamao Endo
author_sort	Rieko Imae
title	Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
title_short	Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
title_full	Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
title_fullStr	Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
title_full_unstemmed	Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals
title_sort	biosynthetic mechanisms and biological significance of glycerol phosphate-containing glycan in mammals
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/13175f7887cc4a1db2b0afc7890eb03c
work_keys_str_mv	AT riekoimae biosyntheticmechanismsandbiologicalsignificanceofglycerolphosphatecontainingglycaninmammals AT hiroshimanya biosyntheticmechanismsandbiologicalsignificanceofglycerolphosphatecontainingglycaninmammals AT tamaoendo biosyntheticmechanismsandbiologicalsignificanceofglycerolphosphatecontainingglycaninmammals
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Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals

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