Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

Photodynamic therapy (PDT) has been applied in clinical treatment of tumors for a long time. However, insufficient supply of pivotal factors including photosensitizer (PS), light, and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of PDT. Nanoparticles have received an influx o...

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Autores principales:	Donghyun Lee, Soonmin Kwon, Seok-young Jang, Eunyoung Park, Yeeun Lee, Heebeom Koo
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Photodynamic therapy Nanoparticle Tumor-targeting Drug delivery Tissue penetration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/131db7b7f2084c148492686e99487743
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spelling	oai:doaj.org-article:131db7b7f2084c148492686e994877432021-11-04T04:35:35ZOvercoming the obstacles of current photodynamic therapy in tumors using nanoparticles2452-199X10.1016/j.bioactmat.2021.06.019https://doaj.org/article/131db7b7f2084c148492686e994877432022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003054https://doaj.org/toc/2452-199XPhotodynamic therapy (PDT) has been applied in clinical treatment of tumors for a long time. However, insufficient supply of pivotal factors including photosensitizer (PS), light, and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of PDT. Nanoparticles have received an influx of attention as drug carriers, and recent studies have demonstrated their promising potential to overcome the obstacles of PDT in tumor tissue. Physicochemical optimization for passive targeting, ligand modification for active targeting, and stimuli-responsive release achieved efficient delivery of PS to tumor tissue. Various trials using upconversion NPs, two-photon lasers, X-rays, and bioluminescence have provided clues for efficient methods of light delivery to deep tissue. Attempts have been made to overcome unfavorable tumor microenvironments via artificial oxygen generation, Fenton reaction, and combination with other chemical drugs. In this review, we introduce these creative approaches to addressing the hurdles facing PDT in tumors. In particular, the studies that have been validated in animal experiments are preferred in this review over proof-of-concept studies that were only performed in cells.Donghyun LeeSoonmin KwonSeok-young JangEunyoung ParkYeeun LeeHeebeom KooKeAi Communications Co., Ltd.articlePhotodynamic therapyNanoparticleTumor-targetingDrug deliveryTissue penetrationMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 20-34 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Photodynamic therapy Nanoparticle Tumor-targeting Drug delivery Tissue penetration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Photodynamic therapy Nanoparticle Tumor-targeting Drug delivery Tissue penetration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Donghyun Lee Soonmin Kwon Seok-young Jang Eunyoung Park Yeeun Lee Heebeom Koo Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
description	Photodynamic therapy (PDT) has been applied in clinical treatment of tumors for a long time. However, insufficient supply of pivotal factors including photosensitizer (PS), light, and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of PDT. Nanoparticles have received an influx of attention as drug carriers, and recent studies have demonstrated their promising potential to overcome the obstacles of PDT in tumor tissue. Physicochemical optimization for passive targeting, ligand modification for active targeting, and stimuli-responsive release achieved efficient delivery of PS to tumor tissue. Various trials using upconversion NPs, two-photon lasers, X-rays, and bioluminescence have provided clues for efficient methods of light delivery to deep tissue. Attempts have been made to overcome unfavorable tumor microenvironments via artificial oxygen generation, Fenton reaction, and combination with other chemical drugs. In this review, we introduce these creative approaches to addressing the hurdles facing PDT in tumors. In particular, the studies that have been validated in animal experiments are preferred in this review over proof-of-concept studies that were only performed in cells.
format	article
author	Donghyun Lee Soonmin Kwon Seok-young Jang Eunyoung Park Yeeun Lee Heebeom Koo
author_facet	Donghyun Lee Soonmin Kwon Seok-young Jang Eunyoung Park Yeeun Lee Heebeom Koo
author_sort	Donghyun Lee
title	Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
title_short	Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
title_full	Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
title_fullStr	Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
title_full_unstemmed	Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
title_sort	overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/131db7b7f2084c148492686e99487743
work_keys_str_mv	AT donghyunlee overcomingtheobstaclesofcurrentphotodynamictherapyintumorsusingnanoparticles AT soonminkwon overcomingtheobstaclesofcurrentphotodynamictherapyintumorsusingnanoparticles AT seokyoungjang overcomingtheobstaclesofcurrentphotodynamictherapyintumorsusingnanoparticles AT eunyoungpark overcomingtheobstaclesofcurrentphotodynamictherapyintumorsusingnanoparticles AT yeeunlee overcomingtheobstaclesofcurrentphotodynamictherapyintumorsusingnanoparticles AT heebeomkoo overcomingtheobstaclesofcurrentphotodynamictherapyintumorsusingnanoparticles
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Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

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