Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration

Maria P Romero,1,2 Hilde H Buzza,1 Mirian D Stringasci,1 Bianca M Estevão,1 Cecilia CC Silva,3 Marcelo A Pereira-da-Silva,1 Natalia M Inada,1 Vanderlei S Bagnato1 1São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil; 2Departamento de M...

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Autores principales:	Romero MP, Buzza HH, Stringasci MD, Estevão BM, Silva CCC, Pereira-da-Silva MA, Inada NM, Bagnato VS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	graphene oxide photodynamic therapy photothermal therapy cancer treatments nanomedicine nanocomposites based on graphene oxide nanoparticle-based drug delivery systems theranostic. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/13280141e33747f3ba87257c670c1f14
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spelling	oai:doaj.org-article:13280141e33747f3ba87257c670c1f142021-12-02T13:58:20ZGraphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration1178-2013https://doaj.org/article/13280141e33747f3ba87257c670c1f142021-03-01T00:00:00Zhttps://www.dovepress.com/graphene-oxide-theranostic-effect-conjugation-of-photothermal-and-phot-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Maria P Romero,1,2 Hilde H Buzza,1 Mirian D Stringasci,1 Bianca M Estevão,1 Cecilia CC Silva,3 Marcelo A Pereira-da-Silva,1 Natalia M Inada,1 Vanderlei S Bagnato1 1São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil; 2Departamento de Materiales, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Quito, Ecuador; 3MackGraphe, Mackenzie Presbyterian University, São Paulo, São Paulo, BrazilCorrespondence: Maria P RomeroDepartamento de Materiales, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Quito, EcuadorTel +593999008658Email maria.romerom@epn.edu.ecIntroduction: Cancer is the second leading cause of death globally and is responsible, where about 1 in 6 deaths in the world. Therefore, there is a need to develop effective antitumor agents that are targeted only to the specific site of the tumor to improve the efficiency of cancer diagnosis and treatment and, consequently, limit the unwanted systemic side effects currently obtained by the use of chemotherapeutic agents. In this context, due to its unique physical and chemical properties of graphene oxide (GO), it has attracted interest in biomedicine for cancer therapy.Methods: In this study, we report the in vivo application of nanocomposites based on Graphene Oxide (nc-GO) with surface modified with PEG-folic acid, Rhodamine B and Indocyanine Green. In addition to displaying red fluorescence spectra Rhodamine B as the fluorescent label), in vivo experiments were performed using nc-GO to apply Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light (808 nm 1.8 W/cm2).Results: This study based on fluorescence images was performed in the tumor in order to obtain the highest concentration of nc-GO in the tumor as a function of time (time after intraperitoneal injection). The time obtained was used for the efficient treatment of the tumor by PDT/PTT.Discussion: The current study shows an example of successful using nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously in vivo fluorescence diagnostic as well as combined PDT-PTT effects for cancer treatments.Keywords: graphene oxide, photodynamic therapy, photothermal therapy, cancer treatments, nanomedicine, nanocomposites based on graphene oxide, nanoparticle-based drug delivery systems, theranosticRomero MPBuzza HHStringasci MDEstevão BMSilva CCCPereira-da-Silva MAInada NMBagnato VSDove Medical Pressarticlegraphene oxidephotodynamic therapyphotothermal therapycancer treatmentsnanomedicinenanocomposites based on graphene oxidenanoparticle-based drug delivery systemstheranostic.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1601-1616 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	graphene oxide photodynamic therapy photothermal therapy cancer treatments nanomedicine nanocomposites based on graphene oxide nanoparticle-based drug delivery systems theranostic. Medicine (General) R5-920
spellingShingle	graphene oxide photodynamic therapy photothermal therapy cancer treatments nanomedicine nanocomposites based on graphene oxide nanoparticle-based drug delivery systems theranostic. Medicine (General) R5-920 Romero MP Buzza HH Stringasci MD Estevão BM Silva CCC Pereira-da-Silva MA Inada NM Bagnato VS Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration
description	Maria P Romero,1,2 Hilde H Buzza,1 Mirian D Stringasci,1 Bianca M Estevão,1 Cecilia CC Silva,3 Marcelo A Pereira-da-Silva,1 Natalia M Inada,1 Vanderlei S Bagnato1 1São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil; 2Departamento de Materiales, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Quito, Ecuador; 3MackGraphe, Mackenzie Presbyterian University, São Paulo, São Paulo, BrazilCorrespondence: Maria P RomeroDepartamento de Materiales, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Quito, EcuadorTel +593999008658Email maria.romerom@epn.edu.ecIntroduction: Cancer is the second leading cause of death globally and is responsible, where about 1 in 6 deaths in the world. Therefore, there is a need to develop effective antitumor agents that are targeted only to the specific site of the tumor to improve the efficiency of cancer diagnosis and treatment and, consequently, limit the unwanted systemic side effects currently obtained by the use of chemotherapeutic agents. In this context, due to its unique physical and chemical properties of graphene oxide (GO), it has attracted interest in biomedicine for cancer therapy.Methods: In this study, we report the in vivo application of nanocomposites based on Graphene Oxide (nc-GO) with surface modified with PEG-folic acid, Rhodamine B and Indocyanine Green. In addition to displaying red fluorescence spectra Rhodamine B as the fluorescent label), in vivo experiments were performed using nc-GO to apply Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light (808 nm 1.8 W/cm2).Results: This study based on fluorescence images was performed in the tumor in order to obtain the highest concentration of nc-GO in the tumor as a function of time (time after intraperitoneal injection). The time obtained was used for the efficient treatment of the tumor by PDT/PTT.Discussion: The current study shows an example of successful using nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously in vivo fluorescence diagnostic as well as combined PDT-PTT effects for cancer treatments.Keywords: graphene oxide, photodynamic therapy, photothermal therapy, cancer treatments, nanomedicine, nanocomposites based on graphene oxide, nanoparticle-based drug delivery systems, theranostic
format	article
author	Romero MP Buzza HH Stringasci MD Estevão BM Silva CCC Pereira-da-Silva MA Inada NM Bagnato VS
author_facet	Romero MP Buzza HH Stringasci MD Estevão BM Silva CCC Pereira-da-Silva MA Inada NM Bagnato VS
author_sort	Romero MP
title	Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration
title_short	Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration
title_full	Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration
title_fullStr	Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration
title_full_unstemmed	Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration
title_sort	graphene oxide theranostic effect: conjugation of photothermal and photodynamic therapies based on an in vivo demonstration
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/13280141e33747f3ba87257c670c1f14
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Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration

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