Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis

Adequate nutritional support and high body mass index (BMI) are good prognostic factors for disease progression and survival in amyotrophic lateral sclerosis (ALS). However, whether the composition of body weight, such as body fat percentage, has an independent effect on ALS prognosis remains unclea...

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Autores principales:	Jin-Woo Park, Minseok Kim, Seol-Hee Baek, Joo Hye Sung, Jae-Guk Yu, Byung-Jo Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	amyotrophic lateral sclerosis body fat percentage oral food intake survival Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/13284331e252426dbbad22f9b75b31e5
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id	oai:doaj.org-article:13284331e252426dbbad22f9b75b31e5
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spelling	oai:doaj.org-article:13284331e252426dbbad22f9b75b31e52021-11-25T18:33:19ZBody Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis10.3390/nu131137042072-6643https://doaj.org/article/13284331e252426dbbad22f9b75b31e52021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3704https://doaj.org/toc/2072-6643Adequate nutritional support and high body mass index (BMI) are good prognostic factors for disease progression and survival in amyotrophic lateral sclerosis (ALS). However, whether the composition of body weight, such as body fat percentage, has an independent effect on ALS prognosis remains unclear. The clinical data of 53 ALS patients were collected by medical record review. The data included: disease onset, sex, age, time of diagnosis, survival duration, presence of percutaneous endoscopic gastrostomy (PEG), nasogastric tube, tracheostomy, and availability of oral intake throughout the course of the disease, and interval measurement values of body mass by bioelectrical impedance analysis (BIA). The interval change (∆) of the BIA parameters was calculated by subtracting the follow-up values from the baseline values. Change in body fat percentage/interval between BIA measurements (months) (hazard ratio [HR] = 0.374, <i>p</i> = 0.0247), and availability of oral food intake (HR = 0.167, <i>p</i> = 0.02), were statistically significant for survival duration in multivariate hazard proportional regression analysis. Survival analysis and Kaplan–Meier curves showed similar results. Higher average monthly change in body fat percentage and availability of oral food intake are prognostic factors in ALS survival.Jin-Woo ParkMinseok KimSeol-Hee BaekJoo Hye SungJae-Guk YuByung-Jo KimMDPI AGarticleamyotrophic lateral sclerosisbody fat percentageoral food intakesurvivalNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3704, p 3704 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyotrophic lateral sclerosis body fat percentage oral food intake survival Nutrition. Foods and food supply TX341-641
spellingShingle	amyotrophic lateral sclerosis body fat percentage oral food intake survival Nutrition. Foods and food supply TX341-641 Jin-Woo Park Minseok Kim Seol-Hee Baek Joo Hye Sung Jae-Guk Yu Byung-Jo Kim Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis
description	Adequate nutritional support and high body mass index (BMI) are good prognostic factors for disease progression and survival in amyotrophic lateral sclerosis (ALS). However, whether the composition of body weight, such as body fat percentage, has an independent effect on ALS prognosis remains unclear. The clinical data of 53 ALS patients were collected by medical record review. The data included: disease onset, sex, age, time of diagnosis, survival duration, presence of percutaneous endoscopic gastrostomy (PEG), nasogastric tube, tracheostomy, and availability of oral intake throughout the course of the disease, and interval measurement values of body mass by bioelectrical impedance analysis (BIA). The interval change (∆) of the BIA parameters was calculated by subtracting the follow-up values from the baseline values. Change in body fat percentage/interval between BIA measurements (months) (hazard ratio [HR] = 0.374, <i>p</i> = 0.0247), and availability of oral food intake (HR = 0.167, <i>p</i> = 0.02), were statistically significant for survival duration in multivariate hazard proportional regression analysis. Survival analysis and Kaplan–Meier curves showed similar results. Higher average monthly change in body fat percentage and availability of oral food intake are prognostic factors in ALS survival.
format	article
author	Jin-Woo Park Minseok Kim Seol-Hee Baek Joo Hye Sung Jae-Guk Yu Byung-Jo Kim
author_facet	Jin-Woo Park Minseok Kim Seol-Hee Baek Joo Hye Sung Jae-Guk Yu Byung-Jo Kim
author_sort	Jin-Woo Park
title	Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis
title_short	Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis
title_full	Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis
title_fullStr	Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis
title_full_unstemmed	Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis
title_sort	body fat percentage and availability of oral food intake: prognostic factors and implications for nutrition in amyotrophic lateral sclerosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/13284331e252426dbbad22f9b75b31e5
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Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis

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