Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and thi...

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Autores principales: Elisabeth Jäger, Supriya Murthy, Caroline Schmidt, Magdalena Hahn, Sarah Strobel, Anna Peters, Claudia Stäubert, Pelin Sungur, Tom Venus, Mandy Geisler, Veselina Radusheva, Stefanie Raps, Kathrin Rothe, Roger Scholz, Sebastian Jung, Sylke Wagner, Matthias Pierer, Olga Seifert, Wenhan Chang, Irina Estrela-Lopis, Nora Raulien, Knut Krohn, Norbert Sträter, Stephanie Hoeppener, Torsten Schöneberg, Manuela Rossol, Ulf Wagner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/13285a5fc1104c3ea401a9b5df22ded9
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spelling oai:doaj.org-article:13285a5fc1104c3ea401a9b5df22ded92021-12-02T16:34:55ZCalcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis10.1038/s41467-020-17749-62041-1723https://doaj.org/article/13285a5fc1104c3ea401a9b5df22ded92020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17749-6https://doaj.org/toc/2041-1723How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and this pathway might be critical to inflammatory conditions.Elisabeth JägerSupriya MurthyCaroline SchmidtMagdalena HahnSarah StrobelAnna PetersClaudia StäubertPelin SungurTom VenusMandy GeislerVeselina RadushevaStefanie RapsKathrin RotheRoger ScholzSebastian JungSylke WagnerMatthias PiererOlga SeifertWenhan ChangIrina Estrela-LopisNora RaulienKnut KrohnNorbert SträterStephanie HoeppenerTorsten SchönebergManuela RossolUlf WagnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elisabeth Jäger
Supriya Murthy
Caroline Schmidt
Magdalena Hahn
Sarah Strobel
Anna Peters
Claudia Stäubert
Pelin Sungur
Tom Venus
Mandy Geisler
Veselina Radusheva
Stefanie Raps
Kathrin Rothe
Roger Scholz
Sebastian Jung
Sylke Wagner
Matthias Pierer
Olga Seifert
Wenhan Chang
Irina Estrela-Lopis
Nora Raulien
Knut Krohn
Norbert Sträter
Stephanie Hoeppener
Torsten Schöneberg
Manuela Rossol
Ulf Wagner
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
description How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and this pathway might be critical to inflammatory conditions.
format article
author Elisabeth Jäger
Supriya Murthy
Caroline Schmidt
Magdalena Hahn
Sarah Strobel
Anna Peters
Claudia Stäubert
Pelin Sungur
Tom Venus
Mandy Geisler
Veselina Radusheva
Stefanie Raps
Kathrin Rothe
Roger Scholz
Sebastian Jung
Sylke Wagner
Matthias Pierer
Olga Seifert
Wenhan Chang
Irina Estrela-Lopis
Nora Raulien
Knut Krohn
Norbert Sträter
Stephanie Hoeppener
Torsten Schöneberg
Manuela Rossol
Ulf Wagner
author_facet Elisabeth Jäger
Supriya Murthy
Caroline Schmidt
Magdalena Hahn
Sarah Strobel
Anna Peters
Claudia Stäubert
Pelin Sungur
Tom Venus
Mandy Geisler
Veselina Radusheva
Stefanie Raps
Kathrin Rothe
Roger Scholz
Sebastian Jung
Sylke Wagner
Matthias Pierer
Olga Seifert
Wenhan Chang
Irina Estrela-Lopis
Nora Raulien
Knut Krohn
Norbert Sträter
Stephanie Hoeppener
Torsten Schöneberg
Manuela Rossol
Ulf Wagner
author_sort Elisabeth Jäger
title Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
title_short Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
title_full Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
title_fullStr Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
title_full_unstemmed Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
title_sort calcium-sensing receptor-mediated nlrp3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/13285a5fc1104c3ea401a9b5df22ded9
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