Restriction genes for retroviruses influence the risk of multiple sclerosis.
We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians. A number of dominant human genes encoding factors that restrict retrovirus replication have been known...
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2013
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oai:doaj.org-article:1328f62d57a147d4ab7f50b57ca1381a2021-11-18T08:55:08ZRestriction genes for retroviruses influence the risk of multiple sclerosis.1932-620310.1371/journal.pone.0074063https://doaj.org/article/1328f62d57a147d4ab7f50b57ca1381a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24066097/?tool=EBIhttps://doaj.org/toc/1932-6203We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians. A number of dominant human genes encoding factors that restrict retrovirus replication have been known for a long time. Today human restriction genes for retroviruses include amongst others TRIMs, APOBEC3s, BST2 and TREXs. We have therefore looked for a role of these retroviral restriction genes in MS using genetic epidemiology. We here report that markers in two TRIMs, TRIM5 and TRIM22 and a marker in BST2, associated statistically with the risk of getting MS, while markers in or near APOBEC3s and TREXs showed little or no effect. This indicates that the two TRIMs and BST2 influence the risk of disease and thus supports the hypothesis of a viral involvement.Bjørn A NexøBettina HansenKari K NissenLisa GundestrupThorkild TerkelsenPalle VillesenShervin BahramiThor PetersenFinn S PedersenMagdalena J LaskaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74063 (2013) |
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Medicine R Science Q Bjørn A Nexø Bettina Hansen Kari K Nissen Lisa Gundestrup Thorkild Terkelsen Palle Villesen Shervin Bahrami Thor Petersen Finn S Pedersen Magdalena J Laska Restriction genes for retroviruses influence the risk of multiple sclerosis. |
| description |
We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians. A number of dominant human genes encoding factors that restrict retrovirus replication have been known for a long time. Today human restriction genes for retroviruses include amongst others TRIMs, APOBEC3s, BST2 and TREXs. We have therefore looked for a role of these retroviral restriction genes in MS using genetic epidemiology. We here report that markers in two TRIMs, TRIM5 and TRIM22 and a marker in BST2, associated statistically with the risk of getting MS, while markers in or near APOBEC3s and TREXs showed little or no effect. This indicates that the two TRIMs and BST2 influence the risk of disease and thus supports the hypothesis of a viral involvement. |
| format |
article |
| author |
Bjørn A Nexø Bettina Hansen Kari K Nissen Lisa Gundestrup Thorkild Terkelsen Palle Villesen Shervin Bahrami Thor Petersen Finn S Pedersen Magdalena J Laska |
| author_facet |
Bjørn A Nexø Bettina Hansen Kari K Nissen Lisa Gundestrup Thorkild Terkelsen Palle Villesen Shervin Bahrami Thor Petersen Finn S Pedersen Magdalena J Laska |
| author_sort |
Bjørn A Nexø |
| title |
Restriction genes for retroviruses influence the risk of multiple sclerosis. |
| title_short |
Restriction genes for retroviruses influence the risk of multiple sclerosis. |
| title_full |
Restriction genes for retroviruses influence the risk of multiple sclerosis. |
| title_fullStr |
Restriction genes for retroviruses influence the risk of multiple sclerosis. |
| title_full_unstemmed |
Restriction genes for retroviruses influence the risk of multiple sclerosis. |
| title_sort |
restriction genes for retroviruses influence the risk of multiple sclerosis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/1328f62d57a147d4ab7f50b57ca1381a |
| work_keys_str_mv |
AT bjørnanexø restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT bettinahansen restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT kariknissen restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT lisagundestrup restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT thorkildterkelsen restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT pallevillesen restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT shervinbahrami restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT thorpetersen restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT finnspedersen restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis AT magdalenajlaska restrictiongenesforretrovirusesinfluencetheriskofmultiplesclerosis |
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1718421126424559616 |