Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.

Arterial rupture is a well-recognized cause of sudden death in horses, which mainly affects older horses. The arterial wall is known to stiffen with age, although the underlying age-related histological and biomechanical changes remain unclear. The purpose of this study was to investigate the effect...

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Autores principales:	Lisse Vera, Sofie Muylle, Glenn Van Steenkiste, Patrick Segers, Annelies Decloedt, Koen Chiers, Gunther van Loon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/132b9637107f46f785adcaaa73190f0d
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spelling	oai:doaj.org-article:132b9637107f46f785adcaaa73190f0d2021-12-02T20:15:29ZHistological and biomechanical properties of systemic arteries in young and old Warmblood horses.1932-620310.1371/journal.pone.0253730https://doaj.org/article/132b9637107f46f785adcaaa73190f0d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253730https://doaj.org/toc/1932-6203Arterial rupture is a well-recognized cause of sudden death in horses, which mainly affects older horses. The arterial wall is known to stiffen with age, although the underlying age-related histological and biomechanical changes remain unclear. The purpose of this study was to investigate the effect of aging by histological analysis of the arterial wall and examination of the arterial wall biomechanical properties using an inflation-extension test. Entire circular samples of the proximal and distal aorta, cranial and caudal common carotid, external iliac, femoral and median artery were collected from 6 young (6 years) and 14 old horses (≥15 years). Samples of all arteries were histologically examined and intima media thickness as well as area % of elastin, smooth muscle actin and collagen type I and III were determined. Older horses had a significantly larger intima media thickness and a significantly higher area % of smooth muscle actin compared to young horses. Samples of the proximal and distal aorta, the caudal common carotid and the external iliac artery were mechanically assessed using an in-house developed inflation-extension device with ultrasound analysis. Rupture occurred in a minority of arteries (8/78) at high pressures (between 250-300 mmHg), and mostly occurred in older horses (7/8). Pressure-area, pressure-compliance and pressure-distensibility curves were constructed. A significant difference in the pressure-area curves of the distal aorta, common carotid artery and external iliac artery, the pressure-compliance curves of the proximal aorta and carotid artery and the pressure-distensibility curve of the proximal aorta was observed between young and old horses. Results demonstrate an effect of age on the histological and biomechanical properties of the arterial wall, which might explain why arterial rupture occurs more often in older horses.Lisse VeraSofie MuylleGlenn Van SteenkistePatrick SegersAnnelies DecloedtKoen ChiersGunther van LoonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisse Vera Sofie Muylle Glenn Van Steenkiste Patrick Segers Annelies Decloedt Koen Chiers Gunther van Loon Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.
description	Arterial rupture is a well-recognized cause of sudden death in horses, which mainly affects older horses. The arterial wall is known to stiffen with age, although the underlying age-related histological and biomechanical changes remain unclear. The purpose of this study was to investigate the effect of aging by histological analysis of the arterial wall and examination of the arterial wall biomechanical properties using an inflation-extension test. Entire circular samples of the proximal and distal aorta, cranial and caudal common carotid, external iliac, femoral and median artery were collected from 6 young (6 years) and 14 old horses (≥15 years). Samples of all arteries were histologically examined and intima media thickness as well as area % of elastin, smooth muscle actin and collagen type I and III were determined. Older horses had a significantly larger intima media thickness and a significantly higher area % of smooth muscle actin compared to young horses. Samples of the proximal and distal aorta, the caudal common carotid and the external iliac artery were mechanically assessed using an in-house developed inflation-extension device with ultrasound analysis. Rupture occurred in a minority of arteries (8/78) at high pressures (between 250-300 mmHg), and mostly occurred in older horses (7/8). Pressure-area, pressure-compliance and pressure-distensibility curves were constructed. A significant difference in the pressure-area curves of the distal aorta, common carotid artery and external iliac artery, the pressure-compliance curves of the proximal aorta and carotid artery and the pressure-distensibility curve of the proximal aorta was observed between young and old horses. Results demonstrate an effect of age on the histological and biomechanical properties of the arterial wall, which might explain why arterial rupture occurs more often in older horses.
format	article
author	Lisse Vera Sofie Muylle Glenn Van Steenkiste Patrick Segers Annelies Decloedt Koen Chiers Gunther van Loon
author_facet	Lisse Vera Sofie Muylle Glenn Van Steenkiste Patrick Segers Annelies Decloedt Koen Chiers Gunther van Loon
author_sort	Lisse Vera
title	Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.
title_short	Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.
title_full	Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.
title_fullStr	Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.
title_full_unstemmed	Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.
title_sort	histological and biomechanical properties of systemic arteries in young and old warmblood horses.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/132b9637107f46f785adcaaa73190f0d
work_keys_str_mv	AT lissevera histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses AT sofiemuylle histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses AT glennvansteenkiste histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses AT patricksegers histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses AT anneliesdecloedt histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses AT koenchiers histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses AT gunthervanloon histologicalandbiomechanicalpropertiesofsystemicarteriesinyoungandoldwarmbloodhorses
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Histological and biomechanical properties of systemic arteries in young and old Warmblood horses.

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