Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Abstract Supramolecular self‐assemblies of dendritic peptides with well‐organized nanostructures have great potential as multifunctional biomaterials, yet the complex self‐assembly mechanism hampers their wide exploration. Herein, a self‐stabilized supramolecular assembly (SSA) constructed from a PE...

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Autores principales:	Xiuli Zheng, Dayi Pan, Xiaoting Chen, Lei Wu, Miao Chen, Wenjia Wang, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	colloidal stability dendritic peptides dissipative particle dynamics simulations polymeric conjugates supramolecular assembly transcriptome analysis Science Q
Acceso en línea:	https://doaj.org/article/132c943a529848458ac774a28207eba3
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spelling	oai:doaj.org-article:132c943a529848458ac774a28207eba32021-11-17T08:40:31ZSelf‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy2198-384410.1002/advs.202102741https://doaj.org/article/132c943a529848458ac774a28207eba32021-11-01T00:00:00Zhttps://doi.org/10.1002/advs.202102741https://doaj.org/toc/2198-3844Abstract Supramolecular self‐assemblies of dendritic peptides with well‐organized nanostructures have great potential as multifunctional biomaterials, yet the complex self‐assembly mechanism hampers their wide exploration. Herein, a self‐stabilized supramolecular assembly (SSA) constructed from a PEGylated dendritic peptide conjugate (PEG‐dendritic peptide‐pyropheophorbide a, PDPP), for augmenting tumor retention and therapy, is reported. The supramolecular self‐assembly process of PDPP is concentration‐dependent with multiple morphologies. By tailoring the concentration of PDPP, the supramolecular self‐assembly is driven by noncovalent interactions to form a variety of SSAs (unimolecular micelles, oligomeric aggregates, and multi‐aggregates) with different sizes from nanometer to micrometer. SSAs at 100 nm with a spherical shape possess extremely high stability to prolong blood circulation about 4.8‐fold higher than pyropheophorbide a (Ppa), and enhance tumor retention about eight‐fold higher than Ppa on day 5 after injection, which leads to greatly boosting the in vivo photodynamic therapeutic efficiency. RNA‐seq demonstrates that these effects of SSAs are related to the inhibition of MET‐PI3K‐Akt pathway. Overall, the supramolecular self‐assembly mechanism for the synthetic PEGylated dendritic peptide conjugate sheds new light on the development of supramolecular assemblies for tumor therapy.Xiuli ZhengDayi PanXiaoting ChenLei WuMiao ChenWenjia WangHu ZhangQiyong GongZhongwei GuKui LuoWileyarticlecolloidal stabilitydendritic peptidesdissipative particle dynamics simulationspolymeric conjugatessupramolecular assemblytranscriptome analysisScienceQENAdvanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colloidal stability dendritic peptides dissipative particle dynamics simulations polymeric conjugates supramolecular assembly transcriptome analysis Science Q
spellingShingle	colloidal stability dendritic peptides dissipative particle dynamics simulations polymeric conjugates supramolecular assembly transcriptome analysis Science Q Xiuli Zheng Dayi Pan Xiaoting Chen Lei Wu Miao Chen Wenjia Wang Hu Zhang Qiyong Gong Zhongwei Gu Kui Luo Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy
description	Abstract Supramolecular self‐assemblies of dendritic peptides with well‐organized nanostructures have great potential as multifunctional biomaterials, yet the complex self‐assembly mechanism hampers their wide exploration. Herein, a self‐stabilized supramolecular assembly (SSA) constructed from a PEGylated dendritic peptide conjugate (PEG‐dendritic peptide‐pyropheophorbide a, PDPP), for augmenting tumor retention and therapy, is reported. The supramolecular self‐assembly process of PDPP is concentration‐dependent with multiple morphologies. By tailoring the concentration of PDPP, the supramolecular self‐assembly is driven by noncovalent interactions to form a variety of SSAs (unimolecular micelles, oligomeric aggregates, and multi‐aggregates) with different sizes from nanometer to micrometer. SSAs at 100 nm with a spherical shape possess extremely high stability to prolong blood circulation about 4.8‐fold higher than pyropheophorbide a (Ppa), and enhance tumor retention about eight‐fold higher than Ppa on day 5 after injection, which leads to greatly boosting the in vivo photodynamic therapeutic efficiency. RNA‐seq demonstrates that these effects of SSAs are related to the inhibition of MET‐PI3K‐Akt pathway. Overall, the supramolecular self‐assembly mechanism for the synthetic PEGylated dendritic peptide conjugate sheds new light on the development of supramolecular assemblies for tumor therapy.
format	article
author	Xiuli Zheng Dayi Pan Xiaoting Chen Lei Wu Miao Chen Wenjia Wang Hu Zhang Qiyong Gong Zhongwei Gu Kui Luo
author_facet	Xiuli Zheng Dayi Pan Xiaoting Chen Lei Wu Miao Chen Wenjia Wang Hu Zhang Qiyong Gong Zhongwei Gu Kui Luo
author_sort	Xiuli Zheng
title	Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy
title_short	Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy
title_full	Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy
title_fullStr	Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy
title_full_unstemmed	Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy
title_sort	self‐stabilized supramolecular assemblies constructed from pegylated dendritic peptide conjugate for augmenting tumor retention and therapy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/132c943a529848458ac774a28207eba3
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Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

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