Human norovirus targets enteroendocrine epithelial cells in the small intestine

Human norovirus targets enteroendocrine epithelial cells in the small intestine

Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe...

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Autores principales: Kim Y. Green, Stuart S. Kaufman, Bianca M. Nagata, Natthawan Chaimongkol, Daniel Y. Kim, Eric A. Levenson, Christine M. Tin, Allison Behrle Yardley, Jordan A. Johnson, Ana Beatriz F. Barletta, Khalid M. Khan, Nada A. Yazigi, Sukanya Subramanian, Sangeetha R. Moturi, Thomas M. Fishbein, Ian N. Moore, Stanislav V. Sosnovtsev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/132cb1be73ac4b169398e75cb96b5f8f
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Sumario:Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.

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