Human norovirus targets enteroendocrine epithelial cells in the small intestine
Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe...
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Nature Portfolio
2020
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oai:doaj.org-article:132cb1be73ac4b169398e75cb96b5f8f2021-12-02T15:02:47ZHuman norovirus targets enteroendocrine epithelial cells in the small intestine10.1038/s41467-020-16491-32041-1723https://doaj.org/article/132cb1be73ac4b169398e75cb96b5f8f2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16491-3https://doaj.org/toc/2041-1723Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.Kim Y. GreenStuart S. KaufmanBianca M. NagataNatthawan ChaimongkolDaniel Y. KimEric A. LevensonChristine M. TinAllison Behrle YardleyJordan A. JohnsonAna Beatriz F. BarlettaKhalid M. KhanNada A. YazigiSukanya SubramanianSangeetha R. MoturiThomas M. FishbeinIan N. MooreStanislav V. SosnovtsevNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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Science Q Kim Y. Green Stuart S. Kaufman Bianca M. Nagata Natthawan Chaimongkol Daniel Y. Kim Eric A. Levenson Christine M. Tin Allison Behrle Yardley Jordan A. Johnson Ana Beatriz F. Barletta Khalid M. Khan Nada A. Yazigi Sukanya Subramanian Sangeetha R. Moturi Thomas M. Fishbein Ian N. Moore Stanislav V. Sosnovtsev Human norovirus targets enteroendocrine epithelial cells in the small intestine |
description |
Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis. |
format |
article |
author |
Kim Y. Green Stuart S. Kaufman Bianca M. Nagata Natthawan Chaimongkol Daniel Y. Kim Eric A. Levenson Christine M. Tin Allison Behrle Yardley Jordan A. Johnson Ana Beatriz F. Barletta Khalid M. Khan Nada A. Yazigi Sukanya Subramanian Sangeetha R. Moturi Thomas M. Fishbein Ian N. Moore Stanislav V. Sosnovtsev |
author_facet |
Kim Y. Green Stuart S. Kaufman Bianca M. Nagata Natthawan Chaimongkol Daniel Y. Kim Eric A. Levenson Christine M. Tin Allison Behrle Yardley Jordan A. Johnson Ana Beatriz F. Barletta Khalid M. Khan Nada A. Yazigi Sukanya Subramanian Sangeetha R. Moturi Thomas M. Fishbein Ian N. Moore Stanislav V. Sosnovtsev |
author_sort |
Kim Y. Green |
title |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
title_short |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
title_full |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
title_fullStr |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
title_full_unstemmed |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
title_sort |
human norovirus targets enteroendocrine epithelial cells in the small intestine |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/132cb1be73ac4b169398e75cb96b5f8f |
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