Human norovirus targets enteroendocrine epithelial cells in the small intestine

Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe...

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Autores principales: Kim Y. Green, Stuart S. Kaufman, Bianca M. Nagata, Natthawan Chaimongkol, Daniel Y. Kim, Eric A. Levenson, Christine M. Tin, Allison Behrle Yardley, Jordan A. Johnson, Ana Beatriz F. Barletta, Khalid M. Khan, Nada A. Yazigi, Sukanya Subramanian, Sangeetha R. Moturi, Thomas M. Fishbein, Ian N. Moore, Stanislav V. Sosnovtsev
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/132cb1be73ac4b169398e75cb96b5f8f
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spelling oai:doaj.org-article:132cb1be73ac4b169398e75cb96b5f8f2021-12-02T15:02:47ZHuman norovirus targets enteroendocrine epithelial cells in the small intestine10.1038/s41467-020-16491-32041-1723https://doaj.org/article/132cb1be73ac4b169398e75cb96b5f8f2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16491-3https://doaj.org/toc/2041-1723Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.Kim Y. GreenStuart S. KaufmanBianca M. NagataNatthawan ChaimongkolDaniel Y. KimEric A. LevensonChristine M. TinAllison Behrle YardleyJordan A. JohnsonAna Beatriz F. BarlettaKhalid M. KhanNada A. YazigiSukanya SubramanianSangeetha R. MoturiThomas M. FishbeinIan N. MooreStanislav V. SosnovtsevNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kim Y. Green
Stuart S. Kaufman
Bianca M. Nagata
Natthawan Chaimongkol
Daniel Y. Kim
Eric A. Levenson
Christine M. Tin
Allison Behrle Yardley
Jordan A. Johnson
Ana Beatriz F. Barletta
Khalid M. Khan
Nada A. Yazigi
Sukanya Subramanian
Sangeetha R. Moturi
Thomas M. Fishbein
Ian N. Moore
Stanislav V. Sosnovtsev
Human norovirus targets enteroendocrine epithelial cells in the small intestine
description Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.
format article
author Kim Y. Green
Stuart S. Kaufman
Bianca M. Nagata
Natthawan Chaimongkol
Daniel Y. Kim
Eric A. Levenson
Christine M. Tin
Allison Behrle Yardley
Jordan A. Johnson
Ana Beatriz F. Barletta
Khalid M. Khan
Nada A. Yazigi
Sukanya Subramanian
Sangeetha R. Moturi
Thomas M. Fishbein
Ian N. Moore
Stanislav V. Sosnovtsev
author_facet Kim Y. Green
Stuart S. Kaufman
Bianca M. Nagata
Natthawan Chaimongkol
Daniel Y. Kim
Eric A. Levenson
Christine M. Tin
Allison Behrle Yardley
Jordan A. Johnson
Ana Beatriz F. Barletta
Khalid M. Khan
Nada A. Yazigi
Sukanya Subramanian
Sangeetha R. Moturi
Thomas M. Fishbein
Ian N. Moore
Stanislav V. Sosnovtsev
author_sort Kim Y. Green
title Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_short Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_full Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_fullStr Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_full_unstemmed Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_sort human norovirus targets enteroendocrine epithelial cells in the small intestine
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/132cb1be73ac4b169398e75cb96b5f8f
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