Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease

Abstract Focal segmental glomerulosclerosis (FSGS) is a serious condition leading to kidney failure. We aimed to investigate the clinical characteristics of FSGS and its differences compared with minimal change disease (MCD) using cross-sectional data from the Japan Renal Biopsy Registry. In Analysi...

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Autores principales:	Takaya Ozeki, Shoichi Maruyama, Toshiyuki Imasawa, Takehiko Kawaguchi, Hiroshi Kitamura, Moritoshi Kadomura, Ritsuko Katafuchi, Kazumasa Oka, Hitoshi Yokoyama, Hitoshi Sugiyama, Hiroshi Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/132cdbc49ccf43b8ad6d12d2f09f3853
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spelling	oai:doaj.org-article:132cdbc49ccf43b8ad6d12d2f09f38532021-12-02T13:57:38ZClinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease10.1038/s41598-020-80931-92045-2322https://doaj.org/article/132cdbc49ccf43b8ad6d12d2f09f38532021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80931-9https://doaj.org/toc/2045-2322Abstract Focal segmental glomerulosclerosis (FSGS) is a serious condition leading to kidney failure. We aimed to investigate the clinical characteristics of FSGS and its differences compared with minimal change disease (MCD) using cross-sectional data from the Japan Renal Biopsy Registry. In Analysis 1, primary FSGS (n = 996) were stratified by age into three groups: pediatric (< 18 years), adult (18–64 years), and elderly (≥ 65 years), and clinical characteristics were compared. Clinical diagnosis of nephrotic syndrome (NS) was given to 73.5% (97/132) of the pediatric, 41.2% (256/622) of the adult, and 65.7% (159/242) of the elderly group. In Analysis 2, primary FSGS (n = 306) and MCD (n = 1303) whose clinical diagnosis was nephrotic syndrome (NS) and laboratory data were consistent with NS, were enrolled. Logistic regression analysis was conducted to elucidate the variables which can distinguish FSGS from MCD. On multivariable analysis, higher systolic blood pressure, higher serum albumin, lower eGFR, and presence of hematuria associated with FSGS. In Japanese nationwide registry, primary FSGS patients aged 18–64 years showed lower rate of NS than those in other ages. Among primary nephrotic cases, FSGS showed distinct clinical features from MCD.Takaya OzekiShoichi MaruyamaToshiyuki ImasawaTakehiko KawaguchiHiroshi KitamuraMoritoshi KadomuraRitsuko KatafuchiKazumasa OkaHitoshi YokoyamaHitoshi SugiyamaHiroshi SatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takaya Ozeki Shoichi Maruyama Toshiyuki Imasawa Takehiko Kawaguchi Hiroshi Kitamura Moritoshi Kadomura Ritsuko Katafuchi Kazumasa Oka Hitoshi Yokoyama Hitoshi Sugiyama Hiroshi Sato Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease
description	Abstract Focal segmental glomerulosclerosis (FSGS) is a serious condition leading to kidney failure. We aimed to investigate the clinical characteristics of FSGS and its differences compared with minimal change disease (MCD) using cross-sectional data from the Japan Renal Biopsy Registry. In Analysis 1, primary FSGS (n = 996) were stratified by age into three groups: pediatric (< 18 years), adult (18–64 years), and elderly (≥ 65 years), and clinical characteristics were compared. Clinical diagnosis of nephrotic syndrome (NS) was given to 73.5% (97/132) of the pediatric, 41.2% (256/622) of the adult, and 65.7% (159/242) of the elderly group. In Analysis 2, primary FSGS (n = 306) and MCD (n = 1303) whose clinical diagnosis was nephrotic syndrome (NS) and laboratory data were consistent with NS, were enrolled. Logistic regression analysis was conducted to elucidate the variables which can distinguish FSGS from MCD. On multivariable analysis, higher systolic blood pressure, higher serum albumin, lower eGFR, and presence of hematuria associated with FSGS. In Japanese nationwide registry, primary FSGS patients aged 18–64 years showed lower rate of NS than those in other ages. Among primary nephrotic cases, FSGS showed distinct clinical features from MCD.
format	article
author	Takaya Ozeki Shoichi Maruyama Toshiyuki Imasawa Takehiko Kawaguchi Hiroshi Kitamura Moritoshi Kadomura Ritsuko Katafuchi Kazumasa Oka Hitoshi Yokoyama Hitoshi Sugiyama Hiroshi Sato
author_facet	Takaya Ozeki Shoichi Maruyama Toshiyuki Imasawa Takehiko Kawaguchi Hiroshi Kitamura Moritoshi Kadomura Ritsuko Katafuchi Kazumasa Oka Hitoshi Yokoyama Hitoshi Sugiyama Hiroshi Sato
author_sort	Takaya Ozeki
title	Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease
title_short	Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease
title_full	Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease
title_fullStr	Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease
title_full_unstemmed	Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease
title_sort	clinical manifestations of focal segmental glomerulosclerosis in japan from the japan renal biopsy registry: age stratification and comparison with minimal change disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/132cdbc49ccf43b8ad6d12d2f09f3853
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Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease

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